Patent
US 10,385,390GRAPHENE TRANSISTOR GATED BY CHARGES THROUGH A NANOPORE FOR BIO-MOLECULAR SENSING AND DNA SEQUENCING
Hongbo Peng
US
Copyright © 2026 Matter42. All rights reserved.
Patent
Atlas literature
Patent
US 10,385,390Patent drawings and their descriptions. Click a drawing to enlarge it.
FIG. 1 illustrates a fabrication process of a cross-section graphene nanopore transistor device according to an embodiment. [0010]
FIG. 2A shows a top view of the graphene nanopore transistor device, illustrating the geometry of the buried graphene layer according to an embodiment. [0011]
FIG. 3 is a setup of the graphene nanopore transistor device for DNA and/or RNA sequencing according to an embodiment. [0014]
FIG. 4 is a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0015]
FIG. 5 shows a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0016]
FIG. 6 illustrates a graph of a transistor current pulse according to an embodiment. [0017]
FIG. 7 illustrates a graph of an ionic current pulse according to an embodiment. [0018]
FIG. 8 is a flow chart illustrating a method for differentiating and identifying bases and biomolecules in a nanopore according to an embodiment. [0019]
FIG. 9 is a flow chart illustrating a method for differentiating and identifying bases and biomolecules in a nanopore according to an embodiment. [0020]
FIG. 10 illustrates an example of a computer having capabilities, which may be included in and/or combined with embodiments.
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A method for electrically differentiating bases, the method comprising: providing a reservoir structure separated into two parts by a membrane, wherein a nanopore is formed through the membrane, wherein the membrane comprises a graphene layer and insulating layers, wherein the graphene layer is coupled to first and second metal pads to form a graphene transistor, wherein the first metal pad forms a step on one of the insulating layers such that a bottom surface of the first metal pad is directly on top of the graphene layer and the bottom surface is directly on top of the one of the insulating layers, while another one of the insulating layers is directly on top of the first metal pad, wherein the step of the first metal pad is external to the reservoir structure; and using transistor current flowing through the graphene transistor to differentiate bases, the transistor current being modulated by charges or dipoles passing through the nanopore. Currently amended
The method of claim 1, wherein the nanopore connects the two parts of the reservoir structure. Original
The method of claim 1, wherein the first and second metal pads include titanium. Original
The method of claim 1, wherein the first and second metal pads include palladium. Original
The method of claim 1, wherein the first and second metal pads include gold. Original
The method of claim 1, where the insulating layers include oxide. Original
The method of claim 1, where the insulating layers include nitride. Original
The method of claim 1. wherein the charges or dipoles correspond to a nucleobase of a nucleic acid molecule. Original
The method of claim 1, wherein the charges or dipoles correspond to a bi omolecule. Original
The method of claim 1, wherein the reservoir structure includes ionic buffer. Original
The method of claim 1, wherein the nanopore is configured to pass a protein. Original
The method of claim 1, wherein the nanopore is configured to pass DNA. Original
The method of claim 1, wherein the n anopore is configured to pass RNA. Original
The method of claim 1, wherein the reservoir structure comprises a top part and a bottom part. Original
Layer stacks claimed or described, ordered top of device to substrate.
graphene nanopore transistor
Materials described outside the worked examples.
graphene
C
insulating layers
Additional fabrication and treatment steps described in the patent.
Measurements and analyses referenced in the patent, with their drawing references.
FIG. 1 illustrates a fabrication process of a cross-section graphene nanopore transistor device according to an embodiment. [0010]
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
Thickness | 0.5–100 nm | — |
Related documents with shared materials, methods, properties, or citations.
Patent
Atlas literature
Patent
US 10,385,390Patent drawings and their descriptions. Click a drawing to enlarge it.
FIG. 1 illustrates a fabrication process of a cross-section graphene nanopore transistor device according to an embodiment. [0010]
FIG. 2A shows a top view of the graphene nanopore transistor device, illustrating the geometry of the buried graphene layer according to an embodiment. [0011]
FIG. 3 is a setup of the graphene nanopore transistor device for DNA and/or RNA sequencing according to an embodiment. [0014]
FIG. 4 is a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0015]
FIG. 5 shows a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0016]
FIG. 6 illustrates a graph of a transistor current pulse according to an embodiment. [0017]
FIG. 7 illustrates a graph of an ionic current pulse according to an embodiment. [0018]
FIG. 8 is a flow chart illustrating a method for differentiating and identifying bases and biomolecules in a nanopore according to an embodiment. [0019]
FIG. 9 is a flow chart illustrating a method for differentiating and identifying bases and biomolecules in a nanopore according to an embodiment. [0020]
FIG. 10 illustrates an example of a computer having capabilities, which may be included in and/or combined with embodiments.
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A method for electrically differentiating bases, the method comprising: providing a reservoir structure separated into two parts by a membrane, wherein a nanopore is formed through the membrane, wherein the membrane comprises a graphene layer and insulating layers, wherein the graphene layer is coupled to first and second metal pads to form a graphene transistor, wherein the first metal pad forms a step on one of the insulating layers such that a bottom surface of the first metal pad is directly on top of the graphene layer and the bottom surface is directly on top of the one of the insulating layers, while another one of the insulating layers is directly on top of the first metal pad, wherein the step of the first metal pad is external to the reservoir structure; and using transistor current flowing through the graphene transistor to differentiate bases, the transistor current being modulated by charges or dipoles passing through the nanopore. Currently amended
The method of claim 1, wherein the nanopore connects the two parts of the reservoir structure. Original
The method of claim 1, wherein the first and second metal pads include titanium. Original
The method of claim 1, wherein the first and second metal pads include palladium. Original
The method of claim 1, wherein the first and second metal pads include gold. Original
The method of claim 1, where the insulating layers include oxide. Original
The method of claim 1, where the insulating layers include nitride. Original
The method of claim 1. wherein the charges or dipoles correspond to a nucleobase of a nucleic acid molecule. Original
The method of claim 1, wherein the charges or dipoles correspond to a bi omolecule. Original
The method of claim 1, wherein the reservoir structure includes ionic buffer. Original
The method of claim 1, wherein the nanopore is configured to pass a protein. Original
The method of claim 1, wherein the nanopore is configured to pass DNA. Original
The method of claim 1, wherein the n anopore is configured to pass RNA. Original
The method of claim 1, wherein the reservoir structure comprises a top part and a bottom part. Original
Layer stacks claimed or described, ordered top of device to substrate.
graphene nanopore transistor
Materials described outside the worked examples.
graphene
C
insulating layers
Additional fabrication and treatment steps described in the patent.
Measurements and analyses referenced in the patent, with their drawing references.
FIG. 1 illustrates a fabrication process of a cross-section graphene nanopore transistor device according to an embodiment. [0010]
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
Thickness | 0.5–100 nm | — |
Related documents with shared materials, methods, properties, or citations.
Patent
Atlas literature
Patent
US 10,385,390Patent drawings and their descriptions. Click a drawing to enlarge it.
FIG. 1 illustrates a fabrication process of a cross-section graphene nanopore transistor device according to an embodiment. [0010]
FIG. 2A shows a top view of the graphene nanopore transistor device, illustrating the geometry of the buried graphene layer according to an embodiment. [0011]
FIG. 3 is a setup of the graphene nanopore transistor device for DNA and/or RNA sequencing according to an embodiment. [0014]
FIG. 4 is a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0015]
FIG. 5 shows a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0016]
FIG. 6 illustrates a graph of a transistor current pulse according to an embodiment. [0017]
FIG. 7 illustrates a graph of an ionic current pulse according to an embodiment. [0018]
FIG. 8 is a flow chart illustrating a method for differentiating and identifying bases and biomolecules in a nanopore according to an embodiment. [0019]
FIG. 9 is a flow chart illustrating a method for differentiating and identifying bases and biomolecules in a nanopore according to an embodiment. [0020]
FIG. 10 illustrates an example of a computer having capabilities, which may be included in and/or combined with embodiments.
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A method for electrically differentiating bases, the method comprising: providing a reservoir structure separated into two parts by a membrane, wherein a nanopore is formed through the membrane, wherein the membrane comprises a graphene layer and insulating layers, wherein the graphene layer is coupled to first and second metal pads to form a graphene transistor, wherein the first metal pad forms a step on one of the insulating layers such that a bottom surface of the first metal pad is directly on top of the graphene layer and the bottom surface is directly on top of the one of the insulating layers, while another one of the insulating layers is directly on top of the first metal pad, wherein the step of the first metal pad is external to the reservoir structure; and using transistor current flowing through the graphene transistor to differentiate bases, the transistor current being modulated by charges or dipoles passing through the nanopore. Currently amended
The method of claim 1, wherein the nanopore connects the two parts of the reservoir structure. Original
The method of claim 1, wherein the first and second metal pads include titanium. Original
The method of claim 1, wherein the first and second metal pads include palladium. Original
The method of claim 1, wherein the first and second metal pads include gold. Original
The method of claim 1, where the insulating layers include oxide. Original
The method of claim 1, where the insulating layers include nitride. Original
The method of claim 1. wherein the charges or dipoles correspond to a nucleobase of a nucleic acid molecule. Original
The method of claim 1, wherein the charges or dipoles correspond to a bi omolecule. Original
The method of claim 1, wherein the reservoir structure includes ionic buffer. Original
The method of claim 1, wherein the nanopore is configured to pass a protein. Original
The method of claim 1, wherein the nanopore is configured to pass DNA. Original
The method of claim 1, wherein the n anopore is configured to pass RNA. Original
The method of claim 1, wherein the reservoir structure comprises a top part and a bottom part. Original
Layer stacks claimed or described, ordered top of device to substrate.
graphene nanopore transistor
Materials described outside the worked examples.
graphene
C
insulating layers
Additional fabrication and treatment steps described in the patent.
Measurements and analyses referenced in the patent, with their drawing references.
FIG. 1 illustrates a fabrication process of a cross-section graphene nanopore transistor device according to an embodiment. [0010]
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
Thickness | 0.5–100 nm | — |
Related documents with shared materials, methods, properties, or citations.
Patent
Atlas literature
Patent
US 10,385,390Patent drawings and their descriptions. Click a drawing to enlarge it.
FIG. 1 illustrates a fabrication process of a cross-section graphene nanopore transistor device according to an embodiment. [0010]
FIG. 2A shows a top view of the graphene nanopore transistor device, illustrating the geometry of the buried graphene layer according to an embodiment. [0011]
FIG. 3 is a setup of the graphene nanopore transistor device for DNA and/or RNA sequencing according to an embodiment. [0014]
FIG. 4 is a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0015]
FIG. 5 shows a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0016]
FIG. 6 illustrates a graph of a transistor current pulse according to an embodiment. [0017]
FIG. 7 illustrates a graph of an ionic current pulse according to an embodiment. [0018]
FIG. 8 is a flow chart illustrating a method for differentiating and identifying bases and biomolecules in a nanopore according to an embodiment. [0019]
FIG. 9 is a flow chart illustrating a method for differentiating and identifying bases and biomolecules in a nanopore according to an embodiment. [0020]
FIG. 10 illustrates an example of a computer having capabilities, which may be included in and/or combined with embodiments.
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A method for electrically differentiating bases, the method comprising: providing a reservoir structure separated into two parts by a membrane, wherein a nanopore is formed through the membrane, wherein the membrane comprises a graphene layer and insulating layers, wherein the graphene layer is coupled to first and second metal pads to form a graphene transistor, wherein the first metal pad forms a step on one of the insulating layers such that a bottom surface of the first metal pad is directly on top of the graphene layer and the bottom surface is directly on top of the one of the insulating layers, while another one of the insulating layers is directly on top of the first metal pad, wherein the step of the first metal pad is external to the reservoir structure; and using transistor current flowing through the graphene transistor to differentiate bases, the transistor current being modulated by charges or dipoles passing through the nanopore. Currently amended
The method of claim 1, wherein the nanopore connects the two parts of the reservoir structure. Original
The method of claim 1, wherein the first and second metal pads include titanium. Original
The method of claim 1, wherein the first and second metal pads include palladium. Original
The method of claim 1, wherein the first and second metal pads include gold. Original
The method of claim 1, where the insulating layers include oxide. Original
The method of claim 1, where the insulating layers include nitride. Original
The method of claim 1. wherein the charges or dipoles correspond to a nucleobase of a nucleic acid molecule. Original
The method of claim 1, wherein the charges or dipoles correspond to a bi omolecule. Original
The method of claim 1, wherein the reservoir structure includes ionic buffer. Original
The method of claim 1, wherein the nanopore is configured to pass a protein. Original
The method of claim 1, wherein the nanopore is configured to pass DNA. Original
The method of claim 1, wherein the n anopore is configured to pass RNA. Original
The method of claim 1, wherein the reservoir structure comprises a top part and a bottom part. Original
Layer stacks claimed or described, ordered top of device to substrate.
graphene nanopore transistor
Materials described outside the worked examples.
graphene
C
insulating layers
Additional fabrication and treatment steps described in the patent.
Measurements and analyses referenced in the patent, with their drawing references.
FIG. 1 illustrates a fabrication process of a cross-section graphene nanopore transistor device according to an embodiment. [0010]
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
Thickness | 0.5–100 nm | — |
Related documents with shared materials, methods, properties, or citations.
titanium
Ti
palladium
Pd
gold
Au
oxide
nitride
ionic buffer
silicon nitride (LPCVD Si₃N₄)
Si₃N₄
silicon dioxide (SiO₂)
SiO₂
silicon substrate
Si
Ti/Pd/Au metal pad stack
organic layer (nanopore coating)
FIG. 2A shows a top view of the graphene nanopore transistor device, illustrating the geometry of the buried graphene layer according to an embodiment. [0011]
FIG. 3 is a setup of the graphene nanopore transistor device for DNA and/or RNA sequencing according to an embodiment. [0014]
FIG. 4 is a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0015]
FIG. 5 shows a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0016]
FIG. 6 illustrates a graph of a transistor current pulse according to an embodiment. [0017]
FIG. 6 illustrates a graph of a transistor current pulse according to an embodiment. [0017]
FIG. 7 illustrates a graph of an ionic current pulse according to an embodiment. [0018]
titanium
Ti
palladium
Pd
gold
Au
oxide
nitride
ionic buffer
silicon nitride (LPCVD Si₃N₄)
Si₃N₄
silicon dioxide (SiO₂)
SiO₂
silicon substrate
Si
Ti/Pd/Au metal pad stack
organic layer (nanopore coating)
FIG. 2A shows a top view of the graphene nanopore transistor device, illustrating the geometry of the buried graphene layer according to an embodiment. [0011]
FIG. 3 is a setup of the graphene nanopore transistor device for DNA and/or RNA sequencing according to an embodiment. [0014]
FIG. 4 is a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0015]
FIG. 5 shows a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0016]
FIG. 6 illustrates a graph of a transistor current pulse according to an embodiment. [0017]
FIG. 6 illustrates a graph of a transistor current pulse according to an embodiment. [0017]
FIG. 7 illustrates a graph of an ionic current pulse according to an embodiment. [0018]
titanium
Ti
palladium
Pd
gold
Au
oxide
nitride
ionic buffer
silicon nitride (LPCVD Si₃N₄)
Si₃N₄
silicon dioxide (SiO₂)
SiO₂
silicon substrate
Si
Ti/Pd/Au metal pad stack
organic layer (nanopore coating)
FIG. 2A shows a top view of the graphene nanopore transistor device, illustrating the geometry of the buried graphene layer according to an embodiment. [0011]
FIG. 3 is a setup of the graphene nanopore transistor device for DNA and/or RNA sequencing according to an embodiment. [0014]
FIG. 4 is a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0015]
FIG. 5 shows a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0016]
FIG. 6 illustrates a graph of a transistor current pulse according to an embodiment. [0017]
FIG. 6 illustrates a graph of a transistor current pulse according to an embodiment. [0017]
FIG. 7 illustrates a graph of an ionic current pulse according to an embodiment. [0018]
titanium
Ti
palladium
Pd
gold
Au
oxide
nitride
ionic buffer
silicon nitride (LPCVD Si₃N₄)
Si₃N₄
silicon dioxide (SiO₂)
SiO₂
silicon substrate
Si
Ti/Pd/Au metal pad stack
organic layer (nanopore coating)
FIG. 2A shows a top view of the graphene nanopore transistor device, illustrating the geometry of the buried graphene layer according to an embodiment. [0011]
FIG. 3 is a setup of the graphene nanopore transistor device for DNA and/or RNA sequencing according to an embodiment. [0014]
FIG. 4 is a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0015]
FIG. 5 shows a setup of the graphene nanopore transistor device for biomolecule sensing according to an embodiment. [0016]
FIG. 6 illustrates a graph of a transistor current pulse according to an embodiment. [0017]
FIG. 6 illustrates a graph of a transistor current pulse according to an embodiment. [0017]
FIG. 7 illustrates a graph of an ionic current pulse according to an embodiment. [0018]