Patent
US 11,119,097Title: G RAPHENE-BI O MOLECULE BI O ELECTRONIC DEVICES
Alan T. Johnson, Ye Lu, Joseph J. Mitala, Bohdana Discher
13 June 2013·US
Copyright © 2026 Matter42. All rights reserved.
Patent
Atlas literature
Patent
US 11,119,097Patent drawings and their descriptions. Click a drawing to enlarge it.
FIG. 1 D Schematic of chemical coupling between graphene (bottom) and the protein's histidine tag (top). [0011] Figure 2 presents current-gate voltage …
FIG. 3B Photocurrent responses of YFP-GFET hybrid. Beginning at time 50 se c, the sample is illuminated for 50 se c and then the light is turned off for 50 sec. …
FIG. 4B blue. [0014] Figure 5 presents AFM images of graphene (a) before and (b) after all functionalization steps except protein incubation. Z-scale is 15 nm. …
FIG. 6A AFM image of a monolayer graphene after functionalization process where the diazonium incubation step was omitted and subsequent chemical steps were …
FIG. 7B after functionalization with a non-his-tag protein G. Z-axis scale is 15 nm.
FIG. 8B Raman of the identical graphene after diazonium functionalization. [0017] Figures 9A-9B presents Raman spectroscopy of monolayer graphene before
FIG. 9B functionalization with His-tagged protein G. [0018] Figure 10 illustrates a photocurrent responses of the graphene FET functionalized with diazonium …
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A device, comprising: a biomolecule comprising a fluorescent protein having an optical absorption peak at around a particular wavelength of excitation illumination, the biomolecule being in electronic communication with a graphene body so as to define a hybrid body, the graphene body being in the form of a flat single-atom thick sheet, the hybrid body having a photocurrent response at the particular wavelength of excitation illumination; a monitor configured to monitor the photocurrent response of the hybrid body; and a source of illumination configured to deliver illumination at around the particular wavelength of excitation illumination. Previously presented
The device of claim 1, wherein the protein comprises a histidine tag. Previously presented
The device of claim 1, wherein the protein is bound to the graphene body by a peptide sequence. Previously presented
The device of claim 1, wherein the protein comprises a reactive amino acid. Previously presented
The device of claim 1, wherein the graphene comprises Diimide- activated amidation. Previously presented
The device of claim 1, further comprising a cysteine-graphene linkage. Previously presented
The device of claim 1, whether comprising an amide bond between the protein and graphene, an imine bond between the protein and graphene, a thiourea bond between the protein and graphene, an aminoalcohol bond between the protein and graphene. Previously presented
The device of claim 1, wherein the fluorescent protein comprises a green fluorescent protein, a yellow fluorescent protein, a red fluorescent protein, a cyan fluorescent protein, or any combination thereof. Previously presented
The device of claim 1, wherein the fluorescent protein comprises a fluorescent redox cofactor. Previously presented
The device of claim 1, further comprising a flavoprotein, a heme containing protein wherein an iron has been substituted by zin c, or any combination thereof. Previously presented
The device of claim 1, wherein the fluorescent protein comprises tryptophan. Previously presented
The device of claim 1, wherein the electronic communication between the biomolecule and the graphene body includes an interaction between a nickel-nitriloacetic acid group and a histidine residue. Original
The device of claim 1, wherein the particular wavelength of excitation illumination is a wavelength between about 1 nm and about 900 nm. Original
The device of claim 1, further comprising a plurality of biomolecules having different absorption peaks in electronic communication with the graphene body. Previously presented
The device of claim 1, further comprising a fusion protein. Previously presented
The device of claim 1, further comprising a chitin binding protein, a maltose binding protein, glutathione- S -transferase, an epitope tag, or any combination thereof. Previously presented
Canceled
Canceled
The method of claim 3 1, wherein the sample contains a binding partner complementary to the protein. Withdrawn
Canceled
Canceled
Canceled
Canceled
Canceled
A method, comprising: contacting a biomolecule to a graphene body such that the biomolecule and graphene body are placed into electronic communication with one another. Withdrawn
The method of claim 21, wherein the biomolecule and graphene bodies comprise moieties that bind to one another, coordinate with one another, or both. Withdrawn
The method of claim 21, wherein the biomolecule comprises a protein. Withdrawn
The method of claim 21, wherein the histidine residue interacts with one or more molecules associated with the graphene. Withdrawn
The method of claim 21, further comprising disposing one or more carboxylic acid groups on the graphene body. Withdrawn
The method of claim 21, wherein the electronic communication between the protein and the graphene body includes an interaction between a nickel-nitriloacetic acid group and a histidine residue. Withdrawn
A device, comprising: a graphene body in the form of a flat single-atom thick sheet in electronic communication with a biomolecule that preferentially binds to a binding partner, thereby forming a hybrid body, the biomolecule comprising a green fluorescent protein, a yellow fluorescent protein, a red fluorescent protein, a cyan fluorescent protein, or any combination thereof, the hybrid body exhibiting a measureable photocurrent response when the biomolecule binds to the binding partner. Previously presented
The device of claim 29, wherein further comprising a plurality of biomolecules having different binding partners in electronic communication with the graphene body. Previously presented
Canceled
A method, comprisin g: illuminating a device with a wavelength of illumination, the device comprising a photosensitive protein having an optical absorption peak at around a particular wavelength of illumination, the photosensitive protein being in electronic communication with a body of graphene; and detecting a change in an electronic characteristic of the device. Withdrawn
(Withdrawn and Previously Presented) The method of claim 31, further comprising contacting the protein to a sample. Withdrawn
A method, comprising: contacting a sample to a device comprising a graphene body in electronic communication with a biomolecule that preferentially binds a binding partner, the graphene body being in electronic communication with a device capable of detecting a change in an electronic characteristic of the protein; and monitoring a change in an electronic characteristic of the device related to binding between the biomolecule and binding partner. Withdrawn
Canceled
Layer stacks claimed or described, ordered top of device to substrate.
graphene-fluorescent protein hybrid photodetector device
graphene-fluorescent protein hybrid biosensor device
Materials described outside the worked examples.
graphene
fluorescent protein
Measurements and analyses referenced in the patent, with their drawing references.
FIG. 1 D Schematic of chemical coupling between graphene (bottom) and the protein's histidine tag (top). [0011] Figure 2 presents current-gate voltage …
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
Thickness | 1–1500 nm | — |
Thickness |
Related documents with shared materials, methods, properties, or citations.
Transfer-Free Method for Producing Graphene Thin Film
GRAPHENE OXIDE SHEET, ARTICLE CONTAINING GRAPHENE-CONTAINING SUBSTANCE PRODUCED BY REDUCING THE GRAPHENE OXIDE SHEET, AND PROCESS FOR PRODUCTION OF THE GRAPHENE OXIDE SHEET
Patent
Atlas literature
Patent
US 11,119,097Patent drawings and their descriptions. Click a drawing to enlarge it.
FIG. 1 D Schematic of chemical coupling between graphene (bottom) and the protein's histidine tag (top). [0011] Figure 2 presents current-gate voltage …
FIG. 3B Photocurrent responses of YFP-GFET hybrid. Beginning at time 50 se c, the sample is illuminated for 50 se c and then the light is turned off for 50 sec. …
FIG. 4B blue. [0014] Figure 5 presents AFM images of graphene (a) before and (b) after all functionalization steps except protein incubation. Z-scale is 15 nm. …
FIG. 6A AFM image of a monolayer graphene after functionalization process where the diazonium incubation step was omitted and subsequent chemical steps were …
FIG. 7B after functionalization with a non-his-tag protein G. Z-axis scale is 15 nm.
FIG. 8B Raman of the identical graphene after diazonium functionalization. [0017] Figures 9A-9B presents Raman spectroscopy of monolayer graphene before
FIG. 9B functionalization with His-tagged protein G. [0018] Figure 10 illustrates a photocurrent responses of the graphene FET functionalized with diazonium …
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A device, comprising: a biomolecule comprising a fluorescent protein having an optical absorption peak at around a particular wavelength of excitation illumination, the biomolecule being in electronic communication with a graphene body so as to define a hybrid body, the graphene body being in the form of a flat single-atom thick sheet, the hybrid body having a photocurrent response at the particular wavelength of excitation illumination; a monitor configured to monitor the photocurrent response of the hybrid body; and a source of illumination configured to deliver illumination at around the particular wavelength of excitation illumination. Previously presented
The device of claim 1, wherein the protein comprises a histidine tag. Previously presented
The device of claim 1, wherein the protein is bound to the graphene body by a peptide sequence. Previously presented
The device of claim 1, wherein the protein comprises a reactive amino acid. Previously presented
The device of claim 1, wherein the graphene comprises Diimide- activated amidation. Previously presented
The device of claim 1, further comprising a cysteine-graphene linkage. Previously presented
The device of claim 1, whether comprising an amide bond between the protein and graphene, an imine bond between the protein and graphene, a thiourea bond between the protein and graphene, an aminoalcohol bond between the protein and graphene. Previously presented
The device of claim 1, wherein the fluorescent protein comprises a green fluorescent protein, a yellow fluorescent protein, a red fluorescent protein, a cyan fluorescent protein, or any combination thereof. Previously presented
The device of claim 1, wherein the fluorescent protein comprises a fluorescent redox cofactor. Previously presented
The device of claim 1, further comprising a flavoprotein, a heme containing protein wherein an iron has been substituted by zin c, or any combination thereof. Previously presented
The device of claim 1, wherein the fluorescent protein comprises tryptophan. Previously presented
The device of claim 1, wherein the electronic communication between the biomolecule and the graphene body includes an interaction between a nickel-nitriloacetic acid group and a histidine residue. Original
The device of claim 1, wherein the particular wavelength of excitation illumination is a wavelength between about 1 nm and about 900 nm. Original
The device of claim 1, further comprising a plurality of biomolecules having different absorption peaks in electronic communication with the graphene body. Previously presented
The device of claim 1, further comprising a fusion protein. Previously presented
The device of claim 1, further comprising a chitin binding protein, a maltose binding protein, glutathione- S -transferase, an epitope tag, or any combination thereof. Previously presented
Canceled
Canceled
The method of claim 3 1, wherein the sample contains a binding partner complementary to the protein. Withdrawn
Canceled
Canceled
Canceled
Canceled
Canceled
A method, comprising: contacting a biomolecule to a graphene body such that the biomolecule and graphene body are placed into electronic communication with one another. Withdrawn
The method of claim 21, wherein the biomolecule and graphene bodies comprise moieties that bind to one another, coordinate with one another, or both. Withdrawn
The method of claim 21, wherein the biomolecule comprises a protein. Withdrawn
The method of claim 21, wherein the histidine residue interacts with one or more molecules associated with the graphene. Withdrawn
The method of claim 21, further comprising disposing one or more carboxylic acid groups on the graphene body. Withdrawn
The method of claim 21, wherein the electronic communication between the protein and the graphene body includes an interaction between a nickel-nitriloacetic acid group and a histidine residue. Withdrawn
A device, comprising: a graphene body in the form of a flat single-atom thick sheet in electronic communication with a biomolecule that preferentially binds to a binding partner, thereby forming a hybrid body, the biomolecule comprising a green fluorescent protein, a yellow fluorescent protein, a red fluorescent protein, a cyan fluorescent protein, or any combination thereof, the hybrid body exhibiting a measureable photocurrent response when the biomolecule binds to the binding partner. Previously presented
The device of claim 29, wherein further comprising a plurality of biomolecules having different binding partners in electronic communication with the graphene body. Previously presented
Canceled
A method, comprisin g: illuminating a device with a wavelength of illumination, the device comprising a photosensitive protein having an optical absorption peak at around a particular wavelength of illumination, the photosensitive protein being in electronic communication with a body of graphene; and detecting a change in an electronic characteristic of the device. Withdrawn
(Withdrawn and Previously Presented) The method of claim 31, further comprising contacting the protein to a sample. Withdrawn
A method, comprising: contacting a sample to a device comprising a graphene body in electronic communication with a biomolecule that preferentially binds a binding partner, the graphene body being in electronic communication with a device capable of detecting a change in an electronic characteristic of the protein; and monitoring a change in an electronic characteristic of the device related to binding between the biomolecule and binding partner. Withdrawn
Canceled
Layer stacks claimed or described, ordered top of device to substrate.
graphene-fluorescent protein hybrid photodetector device
graphene-fluorescent protein hybrid biosensor device
Materials described outside the worked examples.
graphene
fluorescent protein
Measurements and analyses referenced in the patent, with their drawing references.
FIG. 1 D Schematic of chemical coupling between graphene (bottom) and the protein's histidine tag (top). [0011] Figure 2 presents current-gate voltage …
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
Thickness | 1–1500 nm | — |
Thickness |
Related documents with shared materials, methods, properties, or citations.
Transfer-Free Method for Producing Graphene Thin Film
GRAPHENE OXIDE SHEET, ARTICLE CONTAINING GRAPHENE-CONTAINING SUBSTANCE PRODUCED BY REDUCING THE GRAPHENE OXIDE SHEET, AND PROCESS FOR PRODUCTION OF THE GRAPHENE OXIDE SHEET
Patent
Atlas literature
Patent
US 11,119,097Patent drawings and their descriptions. Click a drawing to enlarge it.
FIG. 1 D Schematic of chemical coupling between graphene (bottom) and the protein's histidine tag (top). [0011] Figure 2 presents current-gate voltage …
FIG. 3B Photocurrent responses of YFP-GFET hybrid. Beginning at time 50 se c, the sample is illuminated for 50 se c and then the light is turned off for 50 sec. …
FIG. 4B blue. [0014] Figure 5 presents AFM images of graphene (a) before and (b) after all functionalization steps except protein incubation. Z-scale is 15 nm. …
FIG. 6A AFM image of a monolayer graphene after functionalization process where the diazonium incubation step was omitted and subsequent chemical steps were …
FIG. 7B after functionalization with a non-his-tag protein G. Z-axis scale is 15 nm.
FIG. 8B Raman of the identical graphene after diazonium functionalization. [0017] Figures 9A-9B presents Raman spectroscopy of monolayer graphene before
FIG. 9B functionalization with His-tagged protein G. [0018] Figure 10 illustrates a photocurrent responses of the graphene FET functionalized with diazonium …
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A device, comprising: a biomolecule comprising a fluorescent protein having an optical absorption peak at around a particular wavelength of excitation illumination, the biomolecule being in electronic communication with a graphene body so as to define a hybrid body, the graphene body being in the form of a flat single-atom thick sheet, the hybrid body having a photocurrent response at the particular wavelength of excitation illumination; a monitor configured to monitor the photocurrent response of the hybrid body; and a source of illumination configured to deliver illumination at around the particular wavelength of excitation illumination. Previously presented
The device of claim 1, wherein the protein comprises a histidine tag. Previously presented
The device of claim 1, wherein the protein is bound to the graphene body by a peptide sequence. Previously presented
The device of claim 1, wherein the protein comprises a reactive amino acid. Previously presented
The device of claim 1, wherein the graphene comprises Diimide- activated amidation. Previously presented
The device of claim 1, further comprising a cysteine-graphene linkage. Previously presented
The device of claim 1, whether comprising an amide bond between the protein and graphene, an imine bond between the protein and graphene, a thiourea bond between the protein and graphene, an aminoalcohol bond between the protein and graphene. Previously presented
The device of claim 1, wherein the fluorescent protein comprises a green fluorescent protein, a yellow fluorescent protein, a red fluorescent protein, a cyan fluorescent protein, or any combination thereof. Previously presented
The device of claim 1, wherein the fluorescent protein comprises a fluorescent redox cofactor. Previously presented
The device of claim 1, further comprising a flavoprotein, a heme containing protein wherein an iron has been substituted by zin c, or any combination thereof. Previously presented
The device of claim 1, wherein the fluorescent protein comprises tryptophan. Previously presented
The device of claim 1, wherein the electronic communication between the biomolecule and the graphene body includes an interaction between a nickel-nitriloacetic acid group and a histidine residue. Original
The device of claim 1, wherein the particular wavelength of excitation illumination is a wavelength between about 1 nm and about 900 nm. Original
The device of claim 1, further comprising a plurality of biomolecules having different absorption peaks in electronic communication with the graphene body. Previously presented
The device of claim 1, further comprising a fusion protein. Previously presented
The device of claim 1, further comprising a chitin binding protein, a maltose binding protein, glutathione- S -transferase, an epitope tag, or any combination thereof. Previously presented
Canceled
Canceled
The method of claim 3 1, wherein the sample contains a binding partner complementary to the protein. Withdrawn
Canceled
Canceled
Canceled
Canceled
Canceled
A method, comprising: contacting a biomolecule to a graphene body such that the biomolecule and graphene body are placed into electronic communication with one another. Withdrawn
The method of claim 21, wherein the biomolecule and graphene bodies comprise moieties that bind to one another, coordinate with one another, or both. Withdrawn
The method of claim 21, wherein the biomolecule comprises a protein. Withdrawn
The method of claim 21, wherein the histidine residue interacts with one or more molecules associated with the graphene. Withdrawn
The method of claim 21, further comprising disposing one or more carboxylic acid groups on the graphene body. Withdrawn
The method of claim 21, wherein the electronic communication between the protein and the graphene body includes an interaction between a nickel-nitriloacetic acid group and a histidine residue. Withdrawn
A device, comprising: a graphene body in the form of a flat single-atom thick sheet in electronic communication with a biomolecule that preferentially binds to a binding partner, thereby forming a hybrid body, the biomolecule comprising a green fluorescent protein, a yellow fluorescent protein, a red fluorescent protein, a cyan fluorescent protein, or any combination thereof, the hybrid body exhibiting a measureable photocurrent response when the biomolecule binds to the binding partner. Previously presented
The device of claim 29, wherein further comprising a plurality of biomolecules having different binding partners in electronic communication with the graphene body. Previously presented
Canceled
A method, comprisin g: illuminating a device with a wavelength of illumination, the device comprising a photosensitive protein having an optical absorption peak at around a particular wavelength of illumination, the photosensitive protein being in electronic communication with a body of graphene; and detecting a change in an electronic characteristic of the device. Withdrawn
(Withdrawn and Previously Presented) The method of claim 31, further comprising contacting the protein to a sample. Withdrawn
A method, comprising: contacting a sample to a device comprising a graphene body in electronic communication with a biomolecule that preferentially binds a binding partner, the graphene body being in electronic communication with a device capable of detecting a change in an electronic characteristic of the protein; and monitoring a change in an electronic characteristic of the device related to binding between the biomolecule and binding partner. Withdrawn
Canceled
Layer stacks claimed or described, ordered top of device to substrate.
graphene-fluorescent protein hybrid photodetector device
graphene-fluorescent protein hybrid biosensor device
Materials described outside the worked examples.
graphene
fluorescent protein
Measurements and analyses referenced in the patent, with their drawing references.
FIG. 1 D Schematic of chemical coupling between graphene (bottom) and the protein's histidine tag (top). [0011] Figure 2 presents current-gate voltage …
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
Thickness | 1–1500 nm | — |
Thickness |
Related documents with shared materials, methods, properties, or citations.
Transfer-Free Method for Producing Graphene Thin Film
GRAPHENE OXIDE SHEET, ARTICLE CONTAINING GRAPHENE-CONTAINING SUBSTANCE PRODUCED BY REDUCING THE GRAPHENE OXIDE SHEET, AND PROCESS FOR PRODUCTION OF THE GRAPHENE OXIDE SHEET
Patent
Atlas literature
Patent
US 11,119,097Patent drawings and their descriptions. Click a drawing to enlarge it.
FIG. 1 D Schematic of chemical coupling between graphene (bottom) and the protein's histidine tag (top). [0011] Figure 2 presents current-gate voltage …
FIG. 3B Photocurrent responses of YFP-GFET hybrid. Beginning at time 50 se c, the sample is illuminated for 50 se c and then the light is turned off for 50 sec. …
FIG. 4B blue. [0014] Figure 5 presents AFM images of graphene (a) before and (b) after all functionalization steps except protein incubation. Z-scale is 15 nm. …
FIG. 6A AFM image of a monolayer graphene after functionalization process where the diazonium incubation step was omitted and subsequent chemical steps were …
FIG. 7B after functionalization with a non-his-tag protein G. Z-axis scale is 15 nm.
FIG. 8B Raman of the identical graphene after diazonium functionalization. [0017] Figures 9A-9B presents Raman spectroscopy of monolayer graphene before
FIG. 9B functionalization with His-tagged protein G. [0018] Figure 10 illustrates a photocurrent responses of the graphene FET functionalized with diazonium …
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A device, comprising: a biomolecule comprising a fluorescent protein having an optical absorption peak at around a particular wavelength of excitation illumination, the biomolecule being in electronic communication with a graphene body so as to define a hybrid body, the graphene body being in the form of a flat single-atom thick sheet, the hybrid body having a photocurrent response at the particular wavelength of excitation illumination; a monitor configured to monitor the photocurrent response of the hybrid body; and a source of illumination configured to deliver illumination at around the particular wavelength of excitation illumination. Previously presented
The device of claim 1, wherein the protein comprises a histidine tag. Previously presented
The device of claim 1, wherein the protein is bound to the graphene body by a peptide sequence. Previously presented
The device of claim 1, wherein the protein comprises a reactive amino acid. Previously presented
The device of claim 1, wherein the graphene comprises Diimide- activated amidation. Previously presented
The device of claim 1, further comprising a cysteine-graphene linkage. Previously presented
The device of claim 1, whether comprising an amide bond between the protein and graphene, an imine bond between the protein and graphene, a thiourea bond between the protein and graphene, an aminoalcohol bond between the protein and graphene. Previously presented
The device of claim 1, wherein the fluorescent protein comprises a green fluorescent protein, a yellow fluorescent protein, a red fluorescent protein, a cyan fluorescent protein, or any combination thereof. Previously presented
The device of claim 1, wherein the fluorescent protein comprises a fluorescent redox cofactor. Previously presented
The device of claim 1, further comprising a flavoprotein, a heme containing protein wherein an iron has been substituted by zin c, or any combination thereof. Previously presented
The device of claim 1, wherein the fluorescent protein comprises tryptophan. Previously presented
The device of claim 1, wherein the electronic communication between the biomolecule and the graphene body includes an interaction between a nickel-nitriloacetic acid group and a histidine residue. Original
The device of claim 1, wherein the particular wavelength of excitation illumination is a wavelength between about 1 nm and about 900 nm. Original
The device of claim 1, further comprising a plurality of biomolecules having different absorption peaks in electronic communication with the graphene body. Previously presented
The device of claim 1, further comprising a fusion protein. Previously presented
The device of claim 1, further comprising a chitin binding protein, a maltose binding protein, glutathione- S -transferase, an epitope tag, or any combination thereof. Previously presented
Canceled
Canceled
The method of claim 3 1, wherein the sample contains a binding partner complementary to the protein. Withdrawn
Canceled
Canceled
Canceled
Canceled
Canceled
A method, comprising: contacting a biomolecule to a graphene body such that the biomolecule and graphene body are placed into electronic communication with one another. Withdrawn
The method of claim 21, wherein the biomolecule and graphene bodies comprise moieties that bind to one another, coordinate with one another, or both. Withdrawn
The method of claim 21, wherein the biomolecule comprises a protein. Withdrawn
The method of claim 21, wherein the histidine residue interacts with one or more molecules associated with the graphene. Withdrawn
The method of claim 21, further comprising disposing one or more carboxylic acid groups on the graphene body. Withdrawn
The method of claim 21, wherein the electronic communication between the protein and the graphene body includes an interaction between a nickel-nitriloacetic acid group and a histidine residue. Withdrawn
A device, comprising: a graphene body in the form of a flat single-atom thick sheet in electronic communication with a biomolecule that preferentially binds to a binding partner, thereby forming a hybrid body, the biomolecule comprising a green fluorescent protein, a yellow fluorescent protein, a red fluorescent protein, a cyan fluorescent protein, or any combination thereof, the hybrid body exhibiting a measureable photocurrent response when the biomolecule binds to the binding partner. Previously presented
The device of claim 29, wherein further comprising a plurality of biomolecules having different binding partners in electronic communication with the graphene body. Previously presented
Canceled
A method, comprisin g: illuminating a device with a wavelength of illumination, the device comprising a photosensitive protein having an optical absorption peak at around a particular wavelength of illumination, the photosensitive protein being in electronic communication with a body of graphene; and detecting a change in an electronic characteristic of the device. Withdrawn
(Withdrawn and Previously Presented) The method of claim 31, further comprising contacting the protein to a sample. Withdrawn
A method, comprising: contacting a sample to a device comprising a graphene body in electronic communication with a biomolecule that preferentially binds a binding partner, the graphene body being in electronic communication with a device capable of detecting a change in an electronic characteristic of the protein; and monitoring a change in an electronic characteristic of the device related to binding between the biomolecule and binding partner. Withdrawn
Canceled
Layer stacks claimed or described, ordered top of device to substrate.
graphene-fluorescent protein hybrid photodetector device
graphene-fluorescent protein hybrid biosensor device
Materials described outside the worked examples.
graphene
fluorescent protein
Measurements and analyses referenced in the patent, with their drawing references.
FIG. 1 D Schematic of chemical coupling between graphene (bottom) and the protein's histidine tag (top). [0011] Figure 2 presents current-gate voltage …
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
Thickness | 1–1500 nm | — |
Thickness |
Related documents with shared materials, methods, properties, or citations.
Transfer-Free Method for Producing Graphene Thin Film
GRAPHENE OXIDE SHEET, ARTICLE CONTAINING GRAPHENE-CONTAINING SUBSTANCE PRODUCED BY REDUCING THE GRAPHENE OXIDE SHEET, AND PROCESS FOR PRODUCTION OF THE GRAPHENE OXIDE SHEET
green fluorescent protein
yellow fluorescent protein
red fluorescent protein
cyan fluorescent protein
flavoprotein
heme-containing protein with iron substituted by zinc
FIG. 4B blue. [0014] Figure 5 presents AFM images of graphene (a) before and (b) after all functionalization steps except protein incubation. Z-scale is 15 nm. …
FIG. 6A AFM image of a monolayer graphene after functionalization process where the diazonium incubation step was omitted and subsequent chemical steps were …
FIG. 8B Raman of the identical graphene after diazonium functionalization. [0017] Figures 9A-9B presents Raman spectroscopy of monolayer graphene before
FIG. 9B functionalization with His-tagged protein G. [0018] Figure 10 illustrates a photocurrent responses of the graphene FET functionalized with diazonium …
| — |
Thickness | 300–700 nm | — |
Thickness | 0.8–1 nm | — |
Duration | 1039–1044 Min | — |
Thickness | ≥ 500 nm | — |
Thickness | 1–900 nm | — |
green fluorescent protein
yellow fluorescent protein
red fluorescent protein
cyan fluorescent protein
flavoprotein
heme-containing protein with iron substituted by zinc
FIG. 4B blue. [0014] Figure 5 presents AFM images of graphene (a) before and (b) after all functionalization steps except protein incubation. Z-scale is 15 nm. …
FIG. 6A AFM image of a monolayer graphene after functionalization process where the diazonium incubation step was omitted and subsequent chemical steps were …
FIG. 8B Raman of the identical graphene after diazonium functionalization. [0017] Figures 9A-9B presents Raman spectroscopy of monolayer graphene before
FIG. 9B functionalization with His-tagged protein G. [0018] Figure 10 illustrates a photocurrent responses of the graphene FET functionalized with diazonium …
| — |
Thickness | 300–700 nm | — |
Thickness | 0.8–1 nm | — |
Duration | 1039–1044 Min | — |
Thickness | ≥ 500 nm | — |
Thickness | 1–900 nm | — |
green fluorescent protein
yellow fluorescent protein
red fluorescent protein
cyan fluorescent protein
flavoprotein
heme-containing protein with iron substituted by zinc
FIG. 4B blue. [0014] Figure 5 presents AFM images of graphene (a) before and (b) after all functionalization steps except protein incubation. Z-scale is 15 nm. …
FIG. 6A AFM image of a monolayer graphene after functionalization process where the diazonium incubation step was omitted and subsequent chemical steps were …
FIG. 8B Raman of the identical graphene after diazonium functionalization. [0017] Figures 9A-9B presents Raman spectroscopy of monolayer graphene before
FIG. 9B functionalization with His-tagged protein G. [0018] Figure 10 illustrates a photocurrent responses of the graphene FET functionalized with diazonium …
| — |
Thickness | 300–700 nm | — |
Thickness | 0.8–1 nm | — |
Duration | 1039–1044 Min | — |
Thickness | ≥ 500 nm | — |
Thickness | 1–900 nm | — |
green fluorescent protein
yellow fluorescent protein
red fluorescent protein
cyan fluorescent protein
flavoprotein
heme-containing protein with iron substituted by zinc
FIG. 4B blue. [0014] Figure 5 presents AFM images of graphene (a) before and (b) after all functionalization steps except protein incubation. Z-scale is 15 nm. …
FIG. 6A AFM image of a monolayer graphene after functionalization process where the diazonium incubation step was omitted and subsequent chemical steps were …
FIG. 8B Raman of the identical graphene after diazonium functionalization. [0017] Figures 9A-9B presents Raman spectroscopy of monolayer graphene before
FIG. 9B functionalization with His-tagged protein G. [0018] Figure 10 illustrates a photocurrent responses of the graphene FET functionalized with diazonium …
| — |
Thickness | 300–700 nm | — |
Thickness | 0.8–1 nm | — |
Duration | 1039–1044 Min | — |
Thickness | ≥ 500 nm | — |
Thickness | 1–900 nm | — |