Patent
US 10,525,161A BIOCOMPOSITE OF BIOMINERALIZED GRAPHENE OXIDE AND ITS USE FOR BONE TISSUE ENGINEERING
AMBROSIO, Luigi, RAUCCI, Maria Grazia
2 February 2017·US
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Patent
Atlas literature
Patent
US 10,525,161Patent drawings and their descriptions. Click a drawing to enlarge it.
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
1-2.. Canceled
Canceled
A process for preparing a biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets, the process comprising the steps of: i) providing and sonicating an aqueous solution of graphene oxide to SVG 15747895.08-05-2019.JYYOZATMRXEAPX3.CLM.1.svg 0.16 2.13 Black and white ii) providing an aqueous solution of a Calcium salt selected from nitrate, sulphate, hydrogen sulphate, carbonate, chloride, nitride, and combinations thereof, iii) adding the aqueous solution of step ii) to the aqueous solution of step i), iv) providing an aqueous solution of a phosphorus salt selected from dihydrogen phosphate, hydrogen phosphate, phosphate, dihydrogen phosphite, SVG 15747895.08-05-2019.JYYOZATMRXEAPX3.CLM.2.svg 0.16 4.14 Black and white v) adding the aqueous solution of step iv) to aqueous solution obtained in step iii), and gelating by adjusting to alkaline pH, thus obtaining the biocomposite. Previously presented
The process of claim 3, wherein, in the aqueous solution obtained in step v), the molar ratio between calcium and phosphorus is 1.0 to 3.0. Original
The process of claim 3, further comprising a step vi) of aging the biocomposite obtained in step v) for at least one day at a temperature of at least 50 °C. Previously presented
The process of claim 3, wherein, in step i), the aqueous solution of graphene oxide is sonicated at room temperature for at least 2 hours. Previously presented
The process of claim 3, wherein aqueous solution obtained in step iii) is ultrasonicated at room temperature for at least 20 minutes. Previously presented
The process of claim 3, wherein, after the adjustment to alkaline pH in step v), the aqueous solution is st irr ed at room temperature for at least 1 hour. Previously presented
(Cu rr ently Amended) A biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets obtained by the process of claim 3 or 14. Currently amended
9-13.. Canceled
Canceled
A process for preparing a biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets, the process comprising the steps of: a) providing a first supersatured SBF solution having pH of about 6.5, b) soaking graphene oxide sheets into said first supersatured SBF solution for a period of 65 to 85 hours, c) providing a second supersatured SBF solution having pH of about 6.0, d) soaking graphene oxide sheets obtained from step b) into said second supersatured SBF solution for a period of 40 to 60 hours, and e) rinsing with water and drying the biocomposite. Previously presented
The process of claim 14, wherein both said first supersatured SBF solution and said second supersatured SBF solution are at a temperature of 30 to 40°C. Original
16-17.. Canceled
Canceled
Layer stacks claimed or described, ordered top of device to substrate.
biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets
Materials described outside the worked examples.
hydroxyapatite
Ca₅(PO₄)3(OH)
calcium phosphate
Additional fabrication and treatment steps described in the patent.
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
XRD peaks (2theta) of biocomposite-primary set | — | Ca₅(PO₄)3(OH) |
XRD peaks (2theta) of biocomposite-additional peaks | — |
Related documents with shared materials, methods, properties, or citations.
Patent
Atlas literature
Patent
US 10,525,161Patent drawings and their descriptions. Click a drawing to enlarge it.
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
1-2.. Canceled
Canceled
A process for preparing a biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets, the process comprising the steps of: i) providing and sonicating an aqueous solution of graphene oxide to SVG 15747895.08-05-2019.JYYOZATMRXEAPX3.CLM.1.svg 0.16 2.13 Black and white ii) providing an aqueous solution of a Calcium salt selected from nitrate, sulphate, hydrogen sulphate, carbonate, chloride, nitride, and combinations thereof, iii) adding the aqueous solution of step ii) to the aqueous solution of step i), iv) providing an aqueous solution of a phosphorus salt selected from dihydrogen phosphate, hydrogen phosphate, phosphate, dihydrogen phosphite, SVG 15747895.08-05-2019.JYYOZATMRXEAPX3.CLM.2.svg 0.16 4.14 Black and white v) adding the aqueous solution of step iv) to aqueous solution obtained in step iii), and gelating by adjusting to alkaline pH, thus obtaining the biocomposite. Previously presented
The process of claim 3, wherein, in the aqueous solution obtained in step v), the molar ratio between calcium and phosphorus is 1.0 to 3.0. Original
The process of claim 3, further comprising a step vi) of aging the biocomposite obtained in step v) for at least one day at a temperature of at least 50 °C. Previously presented
The process of claim 3, wherein, in step i), the aqueous solution of graphene oxide is sonicated at room temperature for at least 2 hours. Previously presented
The process of claim 3, wherein aqueous solution obtained in step iii) is ultrasonicated at room temperature for at least 20 minutes. Previously presented
The process of claim 3, wherein, after the adjustment to alkaline pH in step v), the aqueous solution is st irr ed at room temperature for at least 1 hour. Previously presented
(Cu rr ently Amended) A biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets obtained by the process of claim 3 or 14. Currently amended
9-13.. Canceled
Canceled
A process for preparing a biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets, the process comprising the steps of: a) providing a first supersatured SBF solution having pH of about 6.5, b) soaking graphene oxide sheets into said first supersatured SBF solution for a period of 65 to 85 hours, c) providing a second supersatured SBF solution having pH of about 6.0, d) soaking graphene oxide sheets obtained from step b) into said second supersatured SBF solution for a period of 40 to 60 hours, and e) rinsing with water and drying the biocomposite. Previously presented
The process of claim 14, wherein both said first supersatured SBF solution and said second supersatured SBF solution are at a temperature of 30 to 40°C. Original
16-17.. Canceled
Canceled
Layer stacks claimed or described, ordered top of device to substrate.
biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets
Materials described outside the worked examples.
hydroxyapatite
Ca₅(PO₄)3(OH)
calcium phosphate
Additional fabrication and treatment steps described in the patent.
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
XRD peaks (2theta) of biocomposite-primary set | — | Ca₅(PO₄)3(OH) |
XRD peaks (2theta) of biocomposite-additional peaks | — |
Related documents with shared materials, methods, properties, or citations.
Patent
Atlas literature
Patent
US 10,525,161Patent drawings and their descriptions. Click a drawing to enlarge it.
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
1-2.. Canceled
Canceled
A process for preparing a biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets, the process comprising the steps of: i) providing and sonicating an aqueous solution of graphene oxide to SVG 15747895.08-05-2019.JYYOZATMRXEAPX3.CLM.1.svg 0.16 2.13 Black and white ii) providing an aqueous solution of a Calcium salt selected from nitrate, sulphate, hydrogen sulphate, carbonate, chloride, nitride, and combinations thereof, iii) adding the aqueous solution of step ii) to the aqueous solution of step i), iv) providing an aqueous solution of a phosphorus salt selected from dihydrogen phosphate, hydrogen phosphate, phosphate, dihydrogen phosphite, SVG 15747895.08-05-2019.JYYOZATMRXEAPX3.CLM.2.svg 0.16 4.14 Black and white v) adding the aqueous solution of step iv) to aqueous solution obtained in step iii), and gelating by adjusting to alkaline pH, thus obtaining the biocomposite. Previously presented
The process of claim 3, wherein, in the aqueous solution obtained in step v), the molar ratio between calcium and phosphorus is 1.0 to 3.0. Original
The process of claim 3, further comprising a step vi) of aging the biocomposite obtained in step v) for at least one day at a temperature of at least 50 °C. Previously presented
The process of claim 3, wherein, in step i), the aqueous solution of graphene oxide is sonicated at room temperature for at least 2 hours. Previously presented
The process of claim 3, wherein aqueous solution obtained in step iii) is ultrasonicated at room temperature for at least 20 minutes. Previously presented
The process of claim 3, wherein, after the adjustment to alkaline pH in step v), the aqueous solution is st irr ed at room temperature for at least 1 hour. Previously presented
(Cu rr ently Amended) A biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets obtained by the process of claim 3 or 14. Currently amended
9-13.. Canceled
Canceled
A process for preparing a biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets, the process comprising the steps of: a) providing a first supersatured SBF solution having pH of about 6.5, b) soaking graphene oxide sheets into said first supersatured SBF solution for a period of 65 to 85 hours, c) providing a second supersatured SBF solution having pH of about 6.0, d) soaking graphene oxide sheets obtained from step b) into said second supersatured SBF solution for a period of 40 to 60 hours, and e) rinsing with water and drying the biocomposite. Previously presented
The process of claim 14, wherein both said first supersatured SBF solution and said second supersatured SBF solution are at a temperature of 30 to 40°C. Original
16-17.. Canceled
Canceled
Layer stacks claimed or described, ordered top of device to substrate.
biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets
Materials described outside the worked examples.
hydroxyapatite
Ca₅(PO₄)3(OH)
calcium phosphate
Additional fabrication and treatment steps described in the patent.
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
XRD peaks (2theta) of biocomposite-primary set | — | Ca₅(PO₄)3(OH) |
XRD peaks (2theta) of biocomposite-additional peaks | — |
Related documents with shared materials, methods, properties, or citations.
Patent
Atlas literature
Patent
US 10,525,161Patent drawings and their descriptions. Click a drawing to enlarge it.
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
1-2.. Canceled
Canceled
A process for preparing a biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets, the process comprising the steps of: i) providing and sonicating an aqueous solution of graphene oxide to SVG 15747895.08-05-2019.JYYOZATMRXEAPX3.CLM.1.svg 0.16 2.13 Black and white ii) providing an aqueous solution of a Calcium salt selected from nitrate, sulphate, hydrogen sulphate, carbonate, chloride, nitride, and combinations thereof, iii) adding the aqueous solution of step ii) to the aqueous solution of step i), iv) providing an aqueous solution of a phosphorus salt selected from dihydrogen phosphate, hydrogen phosphate, phosphate, dihydrogen phosphite, SVG 15747895.08-05-2019.JYYOZATMRXEAPX3.CLM.2.svg 0.16 4.14 Black and white v) adding the aqueous solution of step iv) to aqueous solution obtained in step iii), and gelating by adjusting to alkaline pH, thus obtaining the biocomposite. Previously presented
The process of claim 3, wherein, in the aqueous solution obtained in step v), the molar ratio between calcium and phosphorus is 1.0 to 3.0. Original
The process of claim 3, further comprising a step vi) of aging the biocomposite obtained in step v) for at least one day at a temperature of at least 50 °C. Previously presented
The process of claim 3, wherein, in step i), the aqueous solution of graphene oxide is sonicated at room temperature for at least 2 hours. Previously presented
The process of claim 3, wherein aqueous solution obtained in step iii) is ultrasonicated at room temperature for at least 20 minutes. Previously presented
The process of claim 3, wherein, after the adjustment to alkaline pH in step v), the aqueous solution is st irr ed at room temperature for at least 1 hour. Previously presented
(Cu rr ently Amended) A biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets obtained by the process of claim 3 or 14. Currently amended
9-13.. Canceled
Canceled
A process for preparing a biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets, the process comprising the steps of: a) providing a first supersatured SBF solution having pH of about 6.5, b) soaking graphene oxide sheets into said first supersatured SBF solution for a period of 65 to 85 hours, c) providing a second supersatured SBF solution having pH of about 6.0, d) soaking graphene oxide sheets obtained from step b) into said second supersatured SBF solution for a period of 40 to 60 hours, and e) rinsing with water and drying the biocomposite. Previously presented
The process of claim 14, wherein both said first supersatured SBF solution and said second supersatured SBF solution are at a temperature of 30 to 40°C. Original
16-17.. Canceled
Canceled
Layer stacks claimed or described, ordered top of device to substrate.
biocomposite of hydroxyapatite and calcium phosphate on graphene oxide sheets
Materials described outside the worked examples.
hydroxyapatite
Ca₅(PO₄)3(OH)
calcium phosphate
Additional fabrication and treatment steps described in the patent.
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
XRD peaks (2theta) of biocomposite-primary set | — | Ca₅(PO₄)3(OH) |
XRD peaks (2theta) of biocomposite-additional peaks | — |
Related documents with shared materials, methods, properties, or citations.
graphene oxide
calcium salt
amorphous calcium phosphate
dicalcium phosphate
dicalcium phosphate dehydrate
Ca/P molar ratio in spindle-like hydroxyapatite nanocrystals | — | Ca₅(PO₄)3(OH) |
Spindle-like HA nanocrystal diameter | — | Ca₅(PO₄)3(OH) |
Spindle-like HA nanocrystal length | — | Ca₅(PO₄)3(OH) |
Thickness | 1–1582 cm | — |
— | 1.5–2 w | — |
Thickness | 500–4000 cm | — |
Thickness | 2-0.5 mM | — |
Temperature | 370–570 °C | — |
Thickness | 550–4000 cm | — |
Temperature | ≤ 5 °C | — |
Temperature | ≥ 50 °C | — |
Duration | 65–85 hours | — |
Duration | 40–60 hours | — |
Temperature | 30–40 °C | — |
Duration | 25–45 minutes | — |
Duration | 2–6 hours | — |
Duration | ≥ 2 hours | — |
Duration | ≥ 6 hours | — |
Duration | ≥ 20 minutes | — |
Duration | ≥ 1 hour | — |
Graphene Oxide/Metal Nanocrystal Multilaminates the Atomic Limit for Safe, Selective Hydrogen Storage
graphene oxide
calcium salt
amorphous calcium phosphate
dicalcium phosphate
dicalcium phosphate dehydrate
Ca/P molar ratio in spindle-like hydroxyapatite nanocrystals | — | Ca₅(PO₄)3(OH) |
Spindle-like HA nanocrystal diameter | — | Ca₅(PO₄)3(OH) |
Spindle-like HA nanocrystal length | — | Ca₅(PO₄)3(OH) |
Thickness | 1–1582 cm | — |
— | 1.5–2 w | — |
Thickness | 500–4000 cm | — |
Thickness | 2-0.5 mM | — |
Temperature | 370–570 °C | — |
Thickness | 550–4000 cm | — |
Temperature | ≤ 5 °C | — |
Temperature | ≥ 50 °C | — |
Duration | 65–85 hours | — |
Duration | 40–60 hours | — |
Temperature | 30–40 °C | — |
Duration | 25–45 minutes | — |
Duration | 2–6 hours | — |
Duration | ≥ 2 hours | — |
Duration | ≥ 6 hours | — |
Duration | ≥ 20 minutes | — |
Duration | ≥ 1 hour | — |
Graphene Oxide/Metal Nanocrystal Multilaminates the Atomic Limit for Safe, Selective Hydrogen Storage
graphene oxide
calcium salt
amorphous calcium phosphate
dicalcium phosphate
dicalcium phosphate dehydrate
Ca/P molar ratio in spindle-like hydroxyapatite nanocrystals | — | Ca₅(PO₄)3(OH) |
Spindle-like HA nanocrystal diameter | — | Ca₅(PO₄)3(OH) |
Spindle-like HA nanocrystal length | — | Ca₅(PO₄)3(OH) |
Thickness | 1–1582 cm | — |
— | 1.5–2 w | — |
Thickness | 500–4000 cm | — |
Thickness | 2-0.5 mM | — |
Temperature | 370–570 °C | — |
Thickness | 550–4000 cm | — |
Temperature | ≤ 5 °C | — |
Temperature | ≥ 50 °C | — |
Duration | 65–85 hours | — |
Duration | 40–60 hours | — |
Temperature | 30–40 °C | — |
Duration | 25–45 minutes | — |
Duration | 2–6 hours | — |
Duration | ≥ 2 hours | — |
Duration | ≥ 6 hours | — |
Duration | ≥ 20 minutes | — |
Duration | ≥ 1 hour | — |
Graphene Oxide/Metal Nanocrystal Multilaminates the Atomic Limit for Safe, Selective Hydrogen Storage
graphene oxide
calcium salt
amorphous calcium phosphate
dicalcium phosphate
dicalcium phosphate dehydrate
Ca/P molar ratio in spindle-like hydroxyapatite nanocrystals | — | Ca₅(PO₄)3(OH) |
Spindle-like HA nanocrystal diameter | — | Ca₅(PO₄)3(OH) |
Spindle-like HA nanocrystal length | — | Ca₅(PO₄)3(OH) |
Thickness | 1–1582 cm | — |
— | 1.5–2 w | — |
Thickness | 500–4000 cm | — |
Thickness | 2-0.5 mM | — |
Temperature | 370–570 °C | — |
Thickness | 550–4000 cm | — |
Temperature | ≤ 5 °C | — |
Temperature | ≥ 50 °C | — |
Duration | 65–85 hours | — |
Duration | 40–60 hours | — |
Temperature | 30–40 °C | — |
Duration | 25–45 minutes | — |
Duration | 2–6 hours | — |
Duration | ≥ 2 hours | — |
Duration | ≥ 6 hours | — |
Duration | ≥ 20 minutes | — |
Duration | ≥ 1 hour | — |
Graphene Oxide/Metal Nanocrystal Multilaminates the Atomic Limit for Safe, Selective Hydrogen Storage