Patent
Atlas literature
Patent
US 10,350,329Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
Canceled
Canceled
An implantable tissue growth structure, wherein the structure is a three-dimensional, biocompatible, biodegradable, electrically conductive structure comprising a network of fibers, the fibers comprising a composite comprising graphene flakes in a polymeric matrix, wherein the composite has a graphene flake content of at least 40 vol. %. Previously presented
The structure of claim 3, wherein the fibers are arranged in an ordered, three-dimensional grid. Original
The structure of claim 3, wherein the graphene flakes along the surfaces of the fibers are preferentially aligned along the long axes of the fibers. Original
The structure of claim 3, wherein the structure is seeded with stem cells. Previously presented
The scaffold of claim 3, wherein the polymeric matrix comprises polylactic acid, glycolic acid, copolymers of polylactic acid and glycolic acid, polycaprolactone, or a mixture thereof. Previously presented
The structure of claim 3, wherein the network of fibers comprises fibers having diameters of 93.5 p m or greater. Previously presented
The structure of claim 3, wherein at least some of the fibers are fused with adjacent, nonparallel fibers. Previously presented
A method for generating electrogenic cells or tissues, the method comprising: contacting a three-dimensional, biocompatible, biodegradable, electrically conductive structure with electrogenic cells or electrogenic tissue, wherein the structure comprises a network of fibers, the fibers comprising a composite of graphene flakes in a polymeric matrix, and further wherein the composite has a graphene flake content of at least 40 vol.%, wherein electrogenic cell generation takes place on the scaffold. Currently amended
The method of claim 8 further comprising contacting the structure with stem cells, wherein the electrogenic cell generation takes place by allowing the stem cells to differentiate into electrogenic cells. Original
-24. Canceled
Canceled
Embodiments described in the patent, grouped by the materials and process steps they use.
3 materials1 process step
A graphene ink (3DG) comprising 60 vol.% graphene flakes and 40 vol.% PLG (polylactic-co-glycolic acid) copolymer in dichloromethane (DCM) solvent is prepared and extruded via direct ink writing through nozzle tips (100–400 µm diameter) to form 3D scaffolds layer-by-layer. Upon extrusion, DCM rapidly evaporates, solidifying fibers with preferential graphene flake alignment along fiber surfaces. Structures including cylinders and sheets are printed, and mechanical and electrical properties are characterized.
Layer stacks claimed or described, ordered top of device to substrate.
implantable tissue growth scaffold
Materials described outside the worked examples.
polylactic acid
glycolic acid
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
electrical resistance of 3DG fiber vs tensile strain | — | graphene flakes |
resistivity of 3DG fibers vs annealing temperature | — |
Patent
Atlas literature
Patent
US 10,350,329Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
Canceled
Canceled
An implantable tissue growth structure, wherein the structure is a three-dimensional, biocompatible, biodegradable, electrically conductive structure comprising a network of fibers, the fibers comprising a composite comprising graphene flakes in a polymeric matrix, wherein the composite has a graphene flake content of at least 40 vol. %. Previously presented
The structure of claim 3, wherein the fibers are arranged in an ordered, three-dimensional grid. Original
The structure of claim 3, wherein the graphene flakes along the surfaces of the fibers are preferentially aligned along the long axes of the fibers. Original
The structure of claim 3, wherein the structure is seeded with stem cells. Previously presented
The scaffold of claim 3, wherein the polymeric matrix comprises polylactic acid, glycolic acid, copolymers of polylactic acid and glycolic acid, polycaprolactone, or a mixture thereof. Previously presented
The structure of claim 3, wherein the network of fibers comprises fibers having diameters of 93.5 p m or greater. Previously presented
The structure of claim 3, wherein at least some of the fibers are fused with adjacent, nonparallel fibers. Previously presented
A method for generating electrogenic cells or tissues, the method comprising: contacting a three-dimensional, biocompatible, biodegradable, electrically conductive structure with electrogenic cells or electrogenic tissue, wherein the structure comprises a network of fibers, the fibers comprising a composite of graphene flakes in a polymeric matrix, and further wherein the composite has a graphene flake content of at least 40 vol.%, wherein electrogenic cell generation takes place on the scaffold. Currently amended
The method of claim 8 further comprising contacting the structure with stem cells, wherein the electrogenic cell generation takes place by allowing the stem cells to differentiate into electrogenic cells. Original
-24. Canceled
Canceled
Embodiments described in the patent, grouped by the materials and process steps they use.
3 materials1 process step
A graphene ink (3DG) comprising 60 vol.% graphene flakes and 40 vol.% PLG (polylactic-co-glycolic acid) copolymer in dichloromethane (DCM) solvent is prepared and extruded via direct ink writing through nozzle tips (100–400 µm diameter) to form 3D scaffolds layer-by-layer. Upon extrusion, DCM rapidly evaporates, solidifying fibers with preferential graphene flake alignment along fiber surfaces. Structures including cylinders and sheets are printed, and mechanical and electrical properties are characterized.
Layer stacks claimed or described, ordered top of device to substrate.
implantable tissue growth scaffold
Materials described outside the worked examples.
polylactic acid
glycolic acid
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
electrical resistance of 3DG fiber vs tensile strain | — | graphene flakes |
resistivity of 3DG fibers vs annealing temperature | — |
Patent
Atlas literature
Patent
US 10,350,329Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
Canceled
Canceled
An implantable tissue growth structure, wherein the structure is a three-dimensional, biocompatible, biodegradable, electrically conductive structure comprising a network of fibers, the fibers comprising a composite comprising graphene flakes in a polymeric matrix, wherein the composite has a graphene flake content of at least 40 vol. %. Previously presented
The structure of claim 3, wherein the fibers are arranged in an ordered, three-dimensional grid. Original
The structure of claim 3, wherein the graphene flakes along the surfaces of the fibers are preferentially aligned along the long axes of the fibers. Original
The structure of claim 3, wherein the structure is seeded with stem cells. Previously presented
The scaffold of claim 3, wherein the polymeric matrix comprises polylactic acid, glycolic acid, copolymers of polylactic acid and glycolic acid, polycaprolactone, or a mixture thereof. Previously presented
The structure of claim 3, wherein the network of fibers comprises fibers having diameters of 93.5 p m or greater. Previously presented
The structure of claim 3, wherein at least some of the fibers are fused with adjacent, nonparallel fibers. Previously presented
A method for generating electrogenic cells or tissues, the method comprising: contacting a three-dimensional, biocompatible, biodegradable, electrically conductive structure with electrogenic cells or electrogenic tissue, wherein the structure comprises a network of fibers, the fibers comprising a composite of graphene flakes in a polymeric matrix, and further wherein the composite has a graphene flake content of at least 40 vol.%, wherein electrogenic cell generation takes place on the scaffold. Currently amended
The method of claim 8 further comprising contacting the structure with stem cells, wherein the electrogenic cell generation takes place by allowing the stem cells to differentiate into electrogenic cells. Original
-24. Canceled
Canceled
Embodiments described in the patent, grouped by the materials and process steps they use.
3 materials1 process step
A graphene ink (3DG) comprising 60 vol.% graphene flakes and 40 vol.% PLG (polylactic-co-glycolic acid) copolymer in dichloromethane (DCM) solvent is prepared and extruded via direct ink writing through nozzle tips (100–400 µm diameter) to form 3D scaffolds layer-by-layer. Upon extrusion, DCM rapidly evaporates, solidifying fibers with preferential graphene flake alignment along fiber surfaces. Structures including cylinders and sheets are printed, and mechanical and electrical properties are characterized.
Layer stacks claimed or described, ordered top of device to substrate.
implantable tissue growth scaffold
Materials described outside the worked examples.
polylactic acid
glycolic acid
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
electrical resistance of 3DG fiber vs tensile strain | — | graphene flakes |
resistivity of 3DG fibers vs annealing temperature | — |
Patent
Atlas literature
Patent
US 10,350,329Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
Canceled
Canceled
An implantable tissue growth structure, wherein the structure is a three-dimensional, biocompatible, biodegradable, electrically conductive structure comprising a network of fibers, the fibers comprising a composite comprising graphene flakes in a polymeric matrix, wherein the composite has a graphene flake content of at least 40 vol. %. Previously presented
The structure of claim 3, wherein the fibers are arranged in an ordered, three-dimensional grid. Original
The structure of claim 3, wherein the graphene flakes along the surfaces of the fibers are preferentially aligned along the long axes of the fibers. Original
The structure of claim 3, wherein the structure is seeded with stem cells. Previously presented
The scaffold of claim 3, wherein the polymeric matrix comprises polylactic acid, glycolic acid, copolymers of polylactic acid and glycolic acid, polycaprolactone, or a mixture thereof. Previously presented
The structure of claim 3, wherein the network of fibers comprises fibers having diameters of 93.5 p m or greater. Previously presented
The structure of claim 3, wherein at least some of the fibers are fused with adjacent, nonparallel fibers. Previously presented
A method for generating electrogenic cells or tissues, the method comprising: contacting a three-dimensional, biocompatible, biodegradable, electrically conductive structure with electrogenic cells or electrogenic tissue, wherein the structure comprises a network of fibers, the fibers comprising a composite of graphene flakes in a polymeric matrix, and further wherein the composite has a graphene flake content of at least 40 vol.%, wherein electrogenic cell generation takes place on the scaffold. Currently amended
The method of claim 8 further comprising contacting the structure with stem cells, wherein the electrogenic cell generation takes place by allowing the stem cells to differentiate into electrogenic cells. Original
-24. Canceled
Canceled
Embodiments described in the patent, grouped by the materials and process steps they use.
3 materials1 process step
A graphene ink (3DG) comprising 60 vol.% graphene flakes and 40 vol.% PLG (polylactic-co-glycolic acid) copolymer in dichloromethane (DCM) solvent is prepared and extruded via direct ink writing through nozzle tips (100–400 µm diameter) to form 3D scaffolds layer-by-layer. Upon extrusion, DCM rapidly evaporates, solidifying fibers with preferential graphene flake alignment along fiber surfaces. Structures including cylinders and sheets are printed, and mechanical and electrical properties are characterized.
Layer stacks claimed or described, ordered top of device to substrate.
implantable tissue growth scaffold
Materials described outside the worked examples.
polylactic acid
glycolic acid
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
electrical resistance of 3DG fiber vs tensile strain | — | graphene flakes |
resistivity of 3DG fibers vs annealing temperature | — |
polycaprolactone
dichloromethane (DCM)
CH₂Cl₂
Pressure | 30–35 Pa | — |
Pressure | ≥ 50 kPa | — |
Temperature | ≥ 150 °C | — |
Pressure | 20–60 kPa | — |
Pressure | 25–55 kPa | — |
Thickness | 100000–1000000 nm | — |
Pressure | 1–2.3 MPa | — |
Thickness | ≥ 1 nm | — |
Thickness | ≥ 50 nm | — |
Thickness | ≥ 1 cm | — |
Thickness | ≥ 10 cm | — |
Temperature | 100–150 °C | — |
polycaprolactone
dichloromethane (DCM)
CH₂Cl₂
Pressure | 30–35 Pa | — |
Pressure | ≥ 50 kPa | — |
Temperature | ≥ 150 °C | — |
Pressure | 20–60 kPa | — |
Pressure | 25–55 kPa | — |
Thickness | 100000–1000000 nm | — |
Pressure | 1–2.3 MPa | — |
Thickness | ≥ 1 nm | — |
Thickness | ≥ 50 nm | — |
Thickness | ≥ 1 cm | — |
Thickness | ≥ 10 cm | — |
Temperature | 100–150 °C | — |
polycaprolactone
dichloromethane (DCM)
CH₂Cl₂
Pressure | 30–35 Pa | — |
Pressure | ≥ 50 kPa | — |
Temperature | ≥ 150 °C | — |
Pressure | 20–60 kPa | — |
Pressure | 25–55 kPa | — |
Thickness | 100000–1000000 nm | — |
Pressure | 1–2.3 MPa | — |
Thickness | ≥ 1 nm | — |
Thickness | ≥ 50 nm | — |
Thickness | ≥ 1 cm | — |
Thickness | ≥ 10 cm | — |
Temperature | 100–150 °C | — |
polycaprolactone
dichloromethane (DCM)
CH₂Cl₂
Pressure | 30–35 Pa | — |
Pressure | ≥ 50 kPa | — |
Temperature | ≥ 150 °C | — |
Pressure | 20–60 kPa | — |
Pressure | 25–55 kPa | — |
Thickness | 100000–1000000 nm | — |
Pressure | 1–2.3 MPa | — |
Thickness | ≥ 1 nm | — |
Thickness | ≥ 50 nm | — |
Thickness | ≥ 1 cm | — |
Thickness | ≥ 10 cm | — |
Temperature | 100–150 °C | — |
