An assay electrode comprising a composite con t aining a matrix and a multiplicity of graphene particles dispersed therein, said assay electrode having a binding domain containing a binding reagent, wherein said binding reagent is immobilized on a surface of said electrode.

An apparatus for conducting an assay comprising: (a) an element comprising i) a matrix; and ii) one or more graphene particles dispersed therein; and (b) binding reagents immobilized on said element to form one or more binding domains capable of binding a component of a binding assay.

An apparatus for use in the detection of an analyte by electrochemiluminescence comprising: (a) an electrode comprising i) a matrix; and ii) one or more graphene particles dispersed therein; and (b) binding reagents immobilized on said electrode to form one or more binding domains containing a reagent capable of binding a component of an electrochemiluminescence assay.

An apparatus for use in the detection of a plurality of analytes by electrochemiluminescence comprising: (a) an electrode comprised of a matrix and a multiplicity of graphene particles dispersed therein; and (b) a plurality of distinct binding domains supported on said electrode, each domain containing a reagent capable of binding a component of a binding electrochemiluminescence assay, wherein at least two of said binding domains differ in their specificity for analytes of interest.

A cassette for use in the detection of analytes in a sample by electrochemiluminescence comprising: (a) a plurality of discrete binding domains on an electrode; and (b) a binding reagent comprising an electrochemiluminescence label; wherein said electrode comprises graphene.

A multi-well plate comprising a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface and a counter electrode surface, wherein said working electrode surface and/or said counter electrode surface comprise screen printed graphene.

A multi-well plate having a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface and a counter electrode surface, wherein said working electrode surface comprises graphene.

A multi-well plate having a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface formed by applying one or more layers of graphene onto a conductive layer comprising silver.

An assay module comprising a substrate having one or more fluid channels for introducing samples and/or assay reagents and one or more working electrode surfaces and one or more counter electrode surfaces on said substrate, wherein said working electrode comprises a graphene ink.

An assay module comprising a working electrode surface and a counter electrode surface, wherein said working electrode surface and said counter electrode surface comprise a printed conductive material comprising graphene.

A multi-well plate comprising a plate top having plate top openings and a plate bottom mated to said plate top to define wells of said multi-well plate, said plate bottom comprising a substrate having a top surface with electrodes patterned thereon and a bottom surface with electrical contacts patterned thereon, wherein said electrodes and contacts are patterned to define two or mor e ind epende ntly addressable sectors of two or more jointly addressable assay wells, each sector comprising two or more wells with: (a) jointly addressable working electrodes on said top surface of said substrate, wherein each of said working electrodes is electrically connected with each other and connected to at least a first of said electrical contacts; and (b) jointly addressable counter electrodes on said top surface of said substrate, wherein each of said counter electrodes is electrically connected with each other, but not with said working electrodes, and connected to at least a second of said electrical contacts, wherein said electrodes comprise graphene.

Canceled

An assay electrode comprising a composite con t aining a matrix and a multiplicity of graphene particles dispersed therein, said assay electrode having a binding domain containing a binding reagent, wherein said binding reagent is immobilized on a surface of said electrode.

An apparatus for conducting an assay comprising: (a) an element comprising i) a matrix; and ii) one or more graphene particles dispersed therein; and (b) binding reagents immobilized on said element to form one or more binding domains capable of binding a component of a binding assay.

An apparatus for use in the detection of an analyte by electrochemiluminescence comprising: (a) an electrode comprising i) a matrix; and ii) one or more graphene particles dispersed therein; and (b) binding reagents immobilized on said electrode to form one or more binding domains containing a reagent capable of binding a component of an electrochemiluminescence assay.

An apparatus for use in the detection of a plurality of analytes by electrochemiluminescence comprising: (a) an electrode comprised of a matrix and a multiplicity of graphene particles dispersed therein; and (b) a plurality of distinct binding domains supported on said electrode, each domain containing a reagent capable of binding a component of a binding electrochemiluminescence assay, wherein at least two of said binding domains differ in their specificity for analytes of interest.

A cassette for use in the detection of analytes in a sample by electrochemiluminescence comprising: (a) a plurality of discrete binding domains on an electrode; and (b) a binding reagent comprising an electrochemiluminescence label; wherein said electrode comprises graphene.

A multi-well plate comprising a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface and a counter electrode surface, wherein said working electrode surface and/or said counter electrode surface comprise screen printed graphene.

A multi-well plate having a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface and a counter electrode surface, wherein said working electrode surface comprises graphene.

A multi-well plate having a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface formed by applying one or more layers of graphene onto a conductive layer comprising silver.

An assay module comprising a substrate having one or more fluid channels for introducing samples and/or assay reagents and one or more working electrode surfaces and one or more counter electrode surfaces on said substrate, wherein said working electrode comprises a graphene ink.

An assay module comprising a working electrode surface and a counter electrode surface, wherein said working electrode surface and said counter electrode surface comprise a printed conductive material comprising graphene.

A multi-well plate comprising a plate top having plate top openings and a plate bottom mated to said plate top to define wells of said multi-well plate, said plate bottom comprising a substrate having a top surface with electrodes patterned thereon and a bottom surface with electrical contacts patterned thereon, wherein said electrodes and contacts are patterned to define two or mor e ind epende ntly addressable sectors of two or more jointly addressable assay wells, each sector comprising two or more wells with: (a) jointly addressable working electrodes on said top surface of said substrate, wherein each of said working electrodes is electrically connected with each other and connected to at least a first of said electrical contacts; and (b) jointly addressable counter electrodes on said top surface of said substrate, wherein each of said counter electrodes is electrically connected with each other, but not with said working electrodes, and connected to at least a second of said electrical contacts, wherein said electrodes comprise graphene.

Canceled

An assay electrode comprising a composite con t aining a matrix and a multiplicity of graphene particles dispersed therein, said assay electrode having a binding domain containing a binding reagent, wherein said binding reagent is immobilized on a surface of said electrode.

An apparatus for conducting an assay comprising: (a) an element comprising i) a matrix; and ii) one or more graphene particles dispersed therein; and (b) binding reagents immobilized on said element to form one or more binding domains capable of binding a component of a binding assay.

An apparatus for use in the detection of an analyte by electrochemiluminescence comprising: (a) an electrode comprising i) a matrix; and ii) one or more graphene particles dispersed therein; and (b) binding reagents immobilized on said electrode to form one or more binding domains containing a reagent capable of binding a component of an electrochemiluminescence assay.

An apparatus for use in the detection of a plurality of analytes by electrochemiluminescence comprising: (a) an electrode comprised of a matrix and a multiplicity of graphene particles dispersed therein; and (b) a plurality of distinct binding domains supported on said electrode, each domain containing a reagent capable of binding a component of a binding electrochemiluminescence assay, wherein at least two of said binding domains differ in their specificity for analytes of interest.

A cassette for use in the detection of analytes in a sample by electrochemiluminescence comprising: (a) a plurality of discrete binding domains on an electrode; and (b) a binding reagent comprising an electrochemiluminescence label; wherein said electrode comprises graphene.

A multi-well plate comprising a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface and a counter electrode surface, wherein said working electrode surface and/or said counter electrode surface comprise screen printed graphene.

A multi-well plate having a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface and a counter electrode surface, wherein said working electrode surface comprises graphene.

A multi-well plate having a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface formed by applying one or more layers of graphene onto a conductive layer comprising silver.

An assay module comprising a substrate having one or more fluid channels for introducing samples and/or assay reagents and one or more working electrode surfaces and one or more counter electrode surfaces on said substrate, wherein said working electrode comprises a graphene ink.

An assay module comprising a working electrode surface and a counter electrode surface, wherein said working electrode surface and said counter electrode surface comprise a printed conductive material comprising graphene.

A multi-well plate comprising a plate top having plate top openings and a plate bottom mated to said plate top to define wells of said multi-well plate, said plate bottom comprising a substrate having a top surface with electrodes patterned thereon and a bottom surface with electrical contacts patterned thereon, wherein said electrodes and contacts are patterned to define two or mor e ind epende ntly addressable sectors of two or more jointly addressable assay wells, each sector comprising two or more wells with: (a) jointly addressable working electrodes on said top surface of said substrate, wherein each of said working electrodes is electrically connected with each other and connected to at least a first of said electrical contacts; and (b) jointly addressable counter electrodes on said top surface of said substrate, wherein each of said counter electrodes is electrically connected with each other, but not with said working electrodes, and connected to at least a second of said electrical contacts, wherein said electrodes comprise graphene.

Canceled

An assay electrode comprising a composite con t aining a matrix and a multiplicity of graphene particles dispersed therein, said assay electrode having a binding domain containing a binding reagent, wherein said binding reagent is immobilized on a surface of said electrode.

An apparatus for conducting an assay comprising: (a) an element comprising i) a matrix; and ii) one or more graphene particles dispersed therein; and (b) binding reagents immobilized on said element to form one or more binding domains capable of binding a component of a binding assay.

An apparatus for use in the detection of an analyte by electrochemiluminescence comprising: (a) an electrode comprising i) a matrix; and ii) one or more graphene particles dispersed therein; and (b) binding reagents immobilized on said electrode to form one or more binding domains containing a reagent capable of binding a component of an electrochemiluminescence assay.

An apparatus for use in the detection of a plurality of analytes by electrochemiluminescence comprising: (a) an electrode comprised of a matrix and a multiplicity of graphene particles dispersed therein; and (b) a plurality of distinct binding domains supported on said electrode, each domain containing a reagent capable of binding a component of a binding electrochemiluminescence assay, wherein at least two of said binding domains differ in their specificity for analytes of interest.

A cassette for use in the detection of analytes in a sample by electrochemiluminescence comprising: (a) a plurality of discrete binding domains on an electrode; and (b) a binding reagent comprising an electrochemiluminescence label; wherein said electrode comprises graphene.

A multi-well plate comprising a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface and a counter electrode surface, wherein said working electrode surface and/or said counter electrode surface comprise screen printed graphene.

A multi-well plate having a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface and a counter electrode surface, wherein said working electrode surface comprises graphene.

A multi-well plate having a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface formed by applying one or more layers of graphene onto a conductive layer comprising silver.

An assay module comprising a substrate having one or more fluid channels for introducing samples and/or assay reagents and one or more working electrode surfaces and one or more counter electrode surfaces on said substrate, wherein said working electrode comprises a graphene ink.

An assay module comprising a working electrode surface and a counter electrode surface, wherein said working electrode surface and said counter electrode surface comprise a printed conductive material comprising graphene.

A multi-well plate comprising a plate top having plate top openings and a plate bottom mated to said plate top to define wells of said multi-well plate, said plate bottom comprising a substrate having a top surface with electrodes patterned thereon and a bottom surface with electrical contacts patterned thereon, wherein said electrodes and contacts are patterned to define two or mor e ind epende ntly addressable sectors of two or more jointly addressable assay wells, each sector comprising two or more wells with: (a) jointly addressable working electrodes on said top surface of said substrate, wherein each of said working electrodes is electrically connected with each other and connected to at least a first of said electrical contacts; and (b) jointly addressable counter electrodes on said top surface of said substrate, wherein each of said counter electrodes is electrically connected with each other, but not with said working electrodes, and connected to at least a second of said electrical contacts, wherein said electrodes comprise graphene.

Canceled