Patent
US 9,833,522GRAPHENE-BASED CONTRAST AGENTS FOR PHOTOACOUSTIC AND THERMOACOUSTIC TOMOGRAPHY AND METHOD OF USE
Balaji Sitharaman
US
Copyright © 2026 Matter42. All rights reserved.
Patent
Atlas literature
Patent
US 9,833,522Patent drawings and their descriptions. Click a drawing to enlarge it.
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A method of performing thermoacoustic imaging of a subject, comprising (a) administering to said subject a sufficient amount of a composition comprising (i) a ma g netic composition com p risin g a ma g netic metal or magnetic metal compound and a graphene nanostructure, wherein the metal or metal com p ound is intercalated in the grap hene nanostructure; and (ii) one or more physiologically acceptable carriers or excipients; and (b) imaging said subject using a photoacoustic or thermoacoustic imaging device. Currently amended
The method of claim 1, wherein said grap hene nanostructure has a thickness of 5 p m or less. Currently amended
The method of claim 1, wherein said graphene[[-like]] nanostructure has a thickness of about 20 nm or less. Currently amended
(C urrently Amended) The method of claim 1, further comprising a water solubilizing moiety attached to said graphene[[-like]] nanostructure. Currently amended
20. The method of claim 1, wherein the composition is dispersed in a 1,2-distear o yl- sn-glycero-3-ph o sph o ethan o lamine-N-amin o(po lyethylene glycol) (DSPE-PEG) o r Plur o nic @. Original
The method of claim 1, wherein said subject is a mammal Original
The method of claim 1, wherein said magnetic metal or metal compound is selected from the group consisting of Mn, Gd, and Fe. New
A method of performing phot o acoustic imaging of a subject, comprising (a) administering to said subject a sufficient amount of a composition comprising (i) a magnetic composition com p risin g a mag netic metal or magnetic metal co mno und and a g raphene nan o structure, wherein the metal o r metal compound is intercalated in the grap hene nan o structure, wherein the grap hene nan o structure is a carbon nan o ribb o n; and (ii) one o r m ore physiologically acceptable carriers o r excipients; and (b) imaging said subject using a phot o acoustic or ther m oac o ustic imaging device. Currently amended
The method of claim 23, wherein the carbon nanoribb o n has a thickness of about 20 nm o r less. Original
The method of claim 23, wherein the carbon nan o ribb o n has an average width in the range of 1 to 25 0 nm and an average length in the range of 200 to 5000 nm. Original
The method of claim 23, wherein the carbon nan o ribb o n has an average width of about 120 nm and an average length in the range of 6 0 0 to 2000 nm. Original
The method of claim 23, wherein said carbon nan o ribbon is an oxidized nanoribb on. Original
28. The method of claim 23, wherein said subject is a mammal 29. The method of claim 28, wherein said mammal is a human. Original
The method of claim 23, wherein said magnetic metal o r metal compound is selected from the group consisting of Mn, Gd, and Fe. New
Materials described outside the worked examples.
graphene nanostructure
magnetic metal
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
Thickness | 1–2 nm | — |
Thickness |
Patent
Atlas literature
Patent
US 9,833,522Patent drawings and their descriptions. Click a drawing to enlarge it.
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A method of performing thermoacoustic imaging of a subject, comprising (a) administering to said subject a sufficient amount of a composition comprising (i) a ma g netic composition com p risin g a ma g netic metal or magnetic metal compound and a graphene nanostructure, wherein the metal or metal com p ound is intercalated in the grap hene nanostructure; and (ii) one or more physiologically acceptable carriers or excipients; and (b) imaging said subject using a photoacoustic or thermoacoustic imaging device. Currently amended
The method of claim 1, wherein said grap hene nanostructure has a thickness of 5 p m or less. Currently amended
The method of claim 1, wherein said graphene[[-like]] nanostructure has a thickness of about 20 nm or less. Currently amended
(C urrently Amended) The method of claim 1, further comprising a water solubilizing moiety attached to said graphene[[-like]] nanostructure. Currently amended
20. The method of claim 1, wherein the composition is dispersed in a 1,2-distear o yl- sn-glycero-3-ph o sph o ethan o lamine-N-amin o(po lyethylene glycol) (DSPE-PEG) o r Plur o nic @. Original
The method of claim 1, wherein said subject is a mammal Original
The method of claim 1, wherein said magnetic metal or metal compound is selected from the group consisting of Mn, Gd, and Fe. New
A method of performing phot o acoustic imaging of a subject, comprising (a) administering to said subject a sufficient amount of a composition comprising (i) a magnetic composition com p risin g a mag netic metal or magnetic metal co mno und and a g raphene nan o structure, wherein the metal o r metal compound is intercalated in the grap hene nan o structure, wherein the grap hene nan o structure is a carbon nan o ribb o n; and (ii) one o r m ore physiologically acceptable carriers o r excipients; and (b) imaging said subject using a phot o acoustic or ther m oac o ustic imaging device. Currently amended
The method of claim 23, wherein the carbon nanoribb o n has a thickness of about 20 nm o r less. Original
The method of claim 23, wherein the carbon nan o ribb o n has an average width in the range of 1 to 25 0 nm and an average length in the range of 200 to 5000 nm. Original
The method of claim 23, wherein the carbon nan o ribb o n has an average width of about 120 nm and an average length in the range of 6 0 0 to 2000 nm. Original
The method of claim 23, wherein said carbon nan o ribbon is an oxidized nanoribb on. Original
28. The method of claim 23, wherein said subject is a mammal 29. The method of claim 28, wherein said mammal is a human. Original
The method of claim 23, wherein said magnetic metal o r metal compound is selected from the group consisting of Mn, Gd, and Fe. New
Materials described outside the worked examples.
graphene nanostructure
magnetic metal
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
Thickness | 1–2 nm | — |
Thickness |
Patent
Atlas literature
Patent
US 9,833,522Patent drawings and their descriptions. Click a drawing to enlarge it.
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A method of performing thermoacoustic imaging of a subject, comprising (a) administering to said subject a sufficient amount of a composition comprising (i) a ma g netic composition com p risin g a ma g netic metal or magnetic metal compound and a graphene nanostructure, wherein the metal or metal com p ound is intercalated in the grap hene nanostructure; and (ii) one or more physiologically acceptable carriers or excipients; and (b) imaging said subject using a photoacoustic or thermoacoustic imaging device. Currently amended
The method of claim 1, wherein said grap hene nanostructure has a thickness of 5 p m or less. Currently amended
The method of claim 1, wherein said graphene[[-like]] nanostructure has a thickness of about 20 nm or less. Currently amended
(C urrently Amended) The method of claim 1, further comprising a water solubilizing moiety attached to said graphene[[-like]] nanostructure. Currently amended
20. The method of claim 1, wherein the composition is dispersed in a 1,2-distear o yl- sn-glycero-3-ph o sph o ethan o lamine-N-amin o(po lyethylene glycol) (DSPE-PEG) o r Plur o nic @. Original
The method of claim 1, wherein said subject is a mammal Original
The method of claim 1, wherein said magnetic metal or metal compound is selected from the group consisting of Mn, Gd, and Fe. New
A method of performing phot o acoustic imaging of a subject, comprising (a) administering to said subject a sufficient amount of a composition comprising (i) a magnetic composition com p risin g a mag netic metal or magnetic metal co mno und and a g raphene nan o structure, wherein the metal o r metal compound is intercalated in the grap hene nan o structure, wherein the grap hene nan o structure is a carbon nan o ribb o n; and (ii) one o r m ore physiologically acceptable carriers o r excipients; and (b) imaging said subject using a phot o acoustic or ther m oac o ustic imaging device. Currently amended
The method of claim 23, wherein the carbon nanoribb o n has a thickness of about 20 nm o r less. Original
The method of claim 23, wherein the carbon nan o ribb o n has an average width in the range of 1 to 25 0 nm and an average length in the range of 200 to 5000 nm. Original
The method of claim 23, wherein the carbon nan o ribb o n has an average width of about 120 nm and an average length in the range of 6 0 0 to 2000 nm. Original
The method of claim 23, wherein said carbon nan o ribbon is an oxidized nanoribb on. Original
28. The method of claim 23, wherein said subject is a mammal 29. The method of claim 28, wherein said mammal is a human. Original
The method of claim 23, wherein said magnetic metal o r metal compound is selected from the group consisting of Mn, Gd, and Fe. New
Materials described outside the worked examples.
graphene nanostructure
magnetic metal
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
Thickness | 1–2 nm | — |
Thickness |
Patent
Atlas literature
Patent
US 9,833,522Patent drawings and their descriptions. Click a drawing to enlarge it.
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A method of performing thermoacoustic imaging of a subject, comprising (a) administering to said subject a sufficient amount of a composition comprising (i) a ma g netic composition com p risin g a ma g netic metal or magnetic metal compound and a graphene nanostructure, wherein the metal or metal com p ound is intercalated in the grap hene nanostructure; and (ii) one or more physiologically acceptable carriers or excipients; and (b) imaging said subject using a photoacoustic or thermoacoustic imaging device. Currently amended
The method of claim 1, wherein said grap hene nanostructure has a thickness of 5 p m or less. Currently amended
The method of claim 1, wherein said graphene[[-like]] nanostructure has a thickness of about 20 nm or less. Currently amended
(C urrently Amended) The method of claim 1, further comprising a water solubilizing moiety attached to said graphene[[-like]] nanostructure. Currently amended
20. The method of claim 1, wherein the composition is dispersed in a 1,2-distear o yl- sn-glycero-3-ph o sph o ethan o lamine-N-amin o(po lyethylene glycol) (DSPE-PEG) o r Plur o nic @. Original
The method of claim 1, wherein said subject is a mammal Original
The method of claim 1, wherein said magnetic metal or metal compound is selected from the group consisting of Mn, Gd, and Fe. New
A method of performing phot o acoustic imaging of a subject, comprising (a) administering to said subject a sufficient amount of a composition comprising (i) a magnetic composition com p risin g a mag netic metal or magnetic metal co mno und and a g raphene nan o structure, wherein the metal o r metal compound is intercalated in the grap hene nan o structure, wherein the grap hene nan o structure is a carbon nan o ribb o n; and (ii) one o r m ore physiologically acceptable carriers o r excipients; and (b) imaging said subject using a phot o acoustic or ther m oac o ustic imaging device. Currently amended
The method of claim 23, wherein the carbon nanoribb o n has a thickness of about 20 nm o r less. Original
The method of claim 23, wherein the carbon nan o ribb o n has an average width in the range of 1 to 25 0 nm and an average length in the range of 200 to 5000 nm. Original
The method of claim 23, wherein the carbon nan o ribb o n has an average width of about 120 nm and an average length in the range of 6 0 0 to 2000 nm. Original
The method of claim 23, wherein said carbon nan o ribbon is an oxidized nanoribb on. Original
28. The method of claim 23, wherein said subject is a mammal 29. The method of claim 28, wherein said mammal is a human. Original
The method of claim 23, wherein said magnetic metal o r metal compound is selected from the group consisting of Mn, Gd, and Fe. New
Materials described outside the worked examples.
graphene nanostructure
magnetic metal
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
Thickness | 1–2 nm | — |
Thickness |
magnetic metal compound
carbon nanoplatelet
oxidized carbon nanoplatelet
carbon nanoribbon
oxidized carbon nanoribbon
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-amino(polyethylene glycol)
Pluronic
Mn
Gd
Fe
oxidized graphene nanoplatelet (O-GNP)
oxidized graphene nanoribbon (O-GNR)
graphitic nano- or microstructure
| — |
Thickness | 60–90 nm | — |
Thickness | 740–845 nm | — |
Thickness | 5–100 nm | — |
Thickness | 10–75 nm | — |
Thickness | 20–50 nm | — |
Thickness | 30–40 nm | — |
Thickness | 5–15 nm | — |
Thickness | 1–5 nm | — |
Thickness | 1–250 nm | — |
Thickness | 10–200 nm | — |
Thickness | 50–150 nm | — |
Thickness | 70–100 nm | — |
Thickness | 200–5000 nm | — |
Thickness | 400–4000 nm | — |
Thickness | 500–3000 nm | — |
Thickness | 600–2000 nm | — |
Thickness | 0–2000 nm | — |
magnetic metal compound
carbon nanoplatelet
oxidized carbon nanoplatelet
carbon nanoribbon
oxidized carbon nanoribbon
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-amino(polyethylene glycol)
Pluronic
Mn
Gd
Fe
oxidized graphene nanoplatelet (O-GNP)
oxidized graphene nanoribbon (O-GNR)
graphitic nano- or microstructure
| — |
Thickness | 60–90 nm | — |
Thickness | 740–845 nm | — |
Thickness | 5–100 nm | — |
Thickness | 10–75 nm | — |
Thickness | 20–50 nm | — |
Thickness | 30–40 nm | — |
Thickness | 5–15 nm | — |
Thickness | 1–5 nm | — |
Thickness | 1–250 nm | — |
Thickness | 10–200 nm | — |
Thickness | 50–150 nm | — |
Thickness | 70–100 nm | — |
Thickness | 200–5000 nm | — |
Thickness | 400–4000 nm | — |
Thickness | 500–3000 nm | — |
Thickness | 600–2000 nm | — |
Thickness | 0–2000 nm | — |
magnetic metal compound
carbon nanoplatelet
oxidized carbon nanoplatelet
carbon nanoribbon
oxidized carbon nanoribbon
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-amino(polyethylene glycol)
Pluronic
Mn
Gd
Fe
oxidized graphene nanoplatelet (O-GNP)
oxidized graphene nanoribbon (O-GNR)
graphitic nano- or microstructure
| — |
Thickness | 60–90 nm | — |
Thickness | 740–845 nm | — |
Thickness | 5–100 nm | — |
Thickness | 10–75 nm | — |
Thickness | 20–50 nm | — |
Thickness | 30–40 nm | — |
Thickness | 5–15 nm | — |
Thickness | 1–5 nm | — |
Thickness | 1–250 nm | — |
Thickness | 10–200 nm | — |
Thickness | 50–150 nm | — |
Thickness | 70–100 nm | — |
Thickness | 200–5000 nm | — |
Thickness | 400–4000 nm | — |
Thickness | 500–3000 nm | — |
Thickness | 600–2000 nm | — |
Thickness | 0–2000 nm | — |
magnetic metal compound
carbon nanoplatelet
oxidized carbon nanoplatelet
carbon nanoribbon
oxidized carbon nanoribbon
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-amino(polyethylene glycol)
Pluronic
Mn
Gd
Fe
oxidized graphene nanoplatelet (O-GNP)
oxidized graphene nanoribbon (O-GNR)
graphitic nano- or microstructure
| — |
Thickness | 60–90 nm | — |
Thickness | 740–845 nm | — |
Thickness | 5–100 nm | — |
Thickness | 10–75 nm | — |
Thickness | 20–50 nm | — |
Thickness | 30–40 nm | — |
Thickness | 5–15 nm | — |
Thickness | 1–5 nm | — |
Thickness | 1–250 nm | — |
Thickness | 10–200 nm | — |
Thickness | 50–150 nm | — |
Thickness | 70–100 nm | — |
Thickness | 200–5000 nm | — |
Thickness | 400–4000 nm | — |
Thickness | 500–3000 nm | — |
Thickness | 600–2000 nm | — |
Thickness | 0–2000 nm | — |