GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

George Y. Wang; Srisharan Murugesan; Aditya P. Rohatgi

doi:10.48550/arxiv.2501.01458

Research paper

Other ComputationalHigh Throughput Screening

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

George Y. Wang, Srisharan Murugesan, Aditya P. Rohatgi

arXiv preprint·2024·10.48550/arxiv.2501.01458·arXiv:2501.01458

Research paper

Other ComputationalHigh Throughput Screening

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

George Y. Wang, Srisharan Murugesan, Aditya P. Rohatgi

arXiv preprint·2024·10.48550/arxiv.2501.01458·arXiv:2501.01458

Research paper

Other ComputationalHigh Throughput Screening

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

George Y. Wang, Srisharan Murugesan, Aditya P. Rohatgi

arXiv preprint·2024·10.48550/arxiv.2501.01458·arXiv:2501.01458

Research paper

Other ComputationalHigh Throughput Screening

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

George Y. Wang, Srisharan Murugesan, Aditya P. Rohatgi

arXiv preprint·2024·10.48550/arxiv.2501.01458·arXiv:2501.01458

Research paper

Other ComputationalHigh Throughput Screening

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

George Y. Wang, Srisharan Murugesan, Aditya P. Rohatgi

arXiv preprint·2024·10.48550/arxiv.2501.01458·arXiv:2501.01458

Research paper

Other ComputationalHigh Throughput Screening

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

George Y. Wang, Srisharan Murugesan, Aditya P. Rohatgi

arXiv preprint·2024·10.48550/arxiv.2501.01458·arXiv:2501.01458

Research paper

Other ComputationalHigh Throughput Screening

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

George Y. Wang, Srisharan Murugesan, Aditya P. Rohatgi

arXiv preprint·2024·10.48550/arxiv.2501.01458·arXiv:2501.01458

Research paper

Other ComputationalHigh Throughput Screening

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

George Y. Wang, Srisharan Murugesan, Aditya P. Rohatgi

arXiv preprint·2024·10.48550/arxiv.2501.01458·arXiv:2501.01458

PIN-based druggable-gene inference dataset evaluated on the Pharos Tclin label set.

4 properties

Simulatedprotein interaction networkStudied Materialgene targetsStudied MaterialPharos Tclin label setReference Material

PIN-based druggable-gene inference dataset evaluated on the Pharos pancreatic intraductal papillary-mucinous neoplasm label set.

3 properties

Simulatedprotein interaction networkStudied Materialgene targetsStudied MaterialPharos pancreatic intraductal papillary-mucinous neoplasm label setReference Material

PIN-based druggable-gene inference dataset evaluated on the Pharos acute myeloid leukemia label set.

3 properties

Simulatedprotein interaction networkStudied Materialgene targetsStudied MaterialPharos acute myeloid leukemia label setReference Material

PIN-based druggable-gene inference dataset evaluated on the Pharos Tclin label set.

4 properties

Simulatedprotein interaction networkStudied Materialgene targetsStudied MaterialPharos Tclin label setReference Material

PIN-based druggable-gene inference dataset evaluated on the Pharos pancreatic intraductal papillary-mucinous neoplasm label set.

3 properties

Simulatedprotein interaction networkStudied Materialgene targetsStudied MaterialPharos pancreatic intraductal papillary-mucinous neoplasm label setReference Material

PIN-based druggable-gene inference dataset evaluated on the Pharos acute myeloid leukemia label set.

3 properties

Simulatedprotein interaction networkStudied Materialgene targetsStudied MaterialPharos acute myeloid leukemia label setReference Material

PIN-based druggable-gene inference dataset evaluated on the Pharos Tclin label set.

4 properties

Simulatedprotein interaction networkStudied Materialgene targetsStudied MaterialPharos Tclin label setReference Material

PIN-based druggable-gene inference dataset evaluated on the Pharos pancreatic intraductal papillary-mucinous neoplasm label set.

3 properties

Simulatedprotein interaction networkStudied Materialgene targetsStudied MaterialPharos pancreatic intraductal papillary-mucinous neoplasm label setReference Material

PIN-based druggable-gene inference dataset evaluated on the Pharos acute myeloid leukemia label set.

3 properties

Simulatedprotein interaction networkStudied Materialgene targetsStudied MaterialPharos acute myeloid leukemia label setReference Material

PIN-based druggable-gene inference dataset evaluated on the Pharos Tclin label set.

4 properties

Simulatedprotein interaction networkStudied Materialgene targetsStudied MaterialPharos Tclin label setReference Material

PIN-based druggable-gene inference dataset evaluated on the Pharos pancreatic intraductal papillary-mucinous neoplasm label set.

3 properties

Simulatedprotein interaction networkStudied Materialgene targetsStudied MaterialPharos pancreatic intraductal papillary-mucinous neoplasm label setReference Material

PIN-based druggable-gene inference dataset evaluated on the Pharos acute myeloid leukemia label set.

3 properties

Simulatedprotein interaction networkStudied Materialgene targetsStudied MaterialPharos acute myeloid leukemia label setReference Material

Type	Label	Value	Material	Sample	Source
Auc Roc	XGBoost + ImGAGN-GraphSAGE (GAN-TAT), Tclin	0.951	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + ImGAGN-GraphSAGE (GAN-TAT), pancreatic	0.919	protein interaction network gene targets Pharos pancreatic intraductal papillary-mucinous neoplasm label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + ImGAGN-GraphSAGE (GAN-TAT), leukemia	0.931	protein interaction network gene targets Pharos acute myeloid leukemia label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + LINE, Tclin	0.947	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + LINE, pancreatic	0.899	protein interaction network gene targets Pharos pancreatic intraductal papillary-mucinous neoplasm label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + LINE, leukemia	0.929	protein interaction network gene targets Pharos acute myeloid leukemia label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + Node2Vec, Tclin	0.94	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + Node2Vec, pancreatic	0.892	protein interaction network gene targets Pharos pancreatic intraductal papillary-mucinous neoplasm label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + Node2Vec, leukemia	0.914	protein interaction network gene targets Pharos acute myeloid leukemia label set	PIN-based druggable-gene inference dataset evaluated on the	—
Fisher Exact P Value	Tclin enrichment in top 5% predictions	<2.4 × 10−266	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—

Type	Label	Value	Material	Sample	Source
Auc Roc	XGBoost + ImGAGN-GraphSAGE (GAN-TAT), Tclin	0.951	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + ImGAGN-GraphSAGE (GAN-TAT), pancreatic	0.919	protein interaction network gene targets Pharos pancreatic intraductal papillary-mucinous neoplasm label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + ImGAGN-GraphSAGE (GAN-TAT), leukemia	0.931	protein interaction network gene targets Pharos acute myeloid leukemia label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + LINE, Tclin	0.947	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + LINE, pancreatic	0.899	protein interaction network gene targets Pharos pancreatic intraductal papillary-mucinous neoplasm label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + LINE, leukemia	0.929	protein interaction network gene targets Pharos acute myeloid leukemia label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + Node2Vec, Tclin	0.94	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + Node2Vec, pancreatic	0.892	protein interaction network gene targets Pharos pancreatic intraductal papillary-mucinous neoplasm label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + Node2Vec, leukemia	0.914	protein interaction network gene targets Pharos acute myeloid leukemia label set	PIN-based druggable-gene inference dataset evaluated on the	—
Fisher Exact P Value	Tclin enrichment in top 5% predictions	<2.4 × 10−266	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—

Type	Label	Value	Material	Sample	Source
Auc Roc	XGBoost + ImGAGN-GraphSAGE (GAN-TAT), Tclin	0.951	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + ImGAGN-GraphSAGE (GAN-TAT), pancreatic	0.919	protein interaction network gene targets Pharos pancreatic intraductal papillary-mucinous neoplasm label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + ImGAGN-GraphSAGE (GAN-TAT), leukemia	0.931	protein interaction network gene targets Pharos acute myeloid leukemia label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + LINE, Tclin	0.947	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + LINE, pancreatic	0.899	protein interaction network gene targets Pharos pancreatic intraductal papillary-mucinous neoplasm label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + LINE, leukemia	0.929	protein interaction network gene targets Pharos acute myeloid leukemia label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + Node2Vec, Tclin	0.94	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + Node2Vec, pancreatic	0.892	protein interaction network gene targets Pharos pancreatic intraductal papillary-mucinous neoplasm label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + Node2Vec, leukemia	0.914	protein interaction network gene targets Pharos acute myeloid leukemia label set	PIN-based druggable-gene inference dataset evaluated on the	—
Fisher Exact P Value	Tclin enrichment in top 5% predictions	<2.4 × 10−266	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—

Type	Label	Value	Material	Sample	Source
Auc Roc	XGBoost + ImGAGN-GraphSAGE (GAN-TAT), Tclin	0.951	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + ImGAGN-GraphSAGE (GAN-TAT), pancreatic	0.919	protein interaction network gene targets Pharos pancreatic intraductal papillary-mucinous neoplasm label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + ImGAGN-GraphSAGE (GAN-TAT), leukemia	0.931	protein interaction network gene targets Pharos acute myeloid leukemia label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + LINE, Tclin	0.947	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + LINE, pancreatic	0.899	protein interaction network gene targets Pharos pancreatic intraductal papillary-mucinous neoplasm label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + LINE, leukemia	0.929	protein interaction network gene targets Pharos acute myeloid leukemia label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + Node2Vec, Tclin	0.94	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + Node2Vec, pancreatic	0.892	protein interaction network gene targets Pharos pancreatic intraductal papillary-mucinous neoplasm label set	PIN-based druggable-gene inference dataset evaluated on the	—
Auc Roc	XGBoost + Node2Vec, leukemia	0.914	protein interaction network gene targets Pharos acute myeloid leukemia label set	PIN-based druggable-gene inference dataset evaluated on the	—
Fisher Exact P Value	Tclin enrichment in top 5% predictions	<2.4 × 10−266	protein interaction network gene targets Pharos Tclin label set	PIN-based druggable-gene inference dataset evaluated on the	—

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

GAN-TAT: A Novel Framework Using Protein Interaction Networks in Druggable Gene Identification

Samples

PIN-based druggable-gene inference dataset evaluated on the Pharos Tclin label set.

PIN-based druggable-gene inference dataset evaluated on the Pharos pancreatic intraductal papillary-mucinous neoplasm label set.

PIN-based druggable-gene inference dataset evaluated on the Pharos acute myeloid leukemia label set.

Materials

Properties

Simulations

Samples

PIN-based druggable-gene inference dataset evaluated on the Pharos Tclin label set.

PIN-based druggable-gene inference dataset evaluated on the Pharos pancreatic intraductal papillary-mucinous neoplasm label set.

PIN-based druggable-gene inference dataset evaluated on the Pharos acute myeloid leukemia label set.

Materials

Properties

Simulations

Samples

PIN-based druggable-gene inference dataset evaluated on the Pharos Tclin label set.

PIN-based druggable-gene inference dataset evaluated on the Pharos pancreatic intraductal papillary-mucinous neoplasm label set.

PIN-based druggable-gene inference dataset evaluated on the Pharos acute myeloid leukemia label set.

Materials

Properties

Simulations

Samples

PIN-based druggable-gene inference dataset evaluated on the Pharos Tclin label set.

PIN-based druggable-gene inference dataset evaluated on the Pharos pancreatic intraductal papillary-mucinous neoplasm label set.

PIN-based druggable-gene inference dataset evaluated on the Pharos acute myeloid leukemia label set.

Materials

Properties

Simulations